Phase 1 MPN Clinical Trials
8 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–8 of 8 trials
Recruiting
Phase 1
A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms
Primary myelofibrosis (PMF)Post-polycythemia Vera MyelofibrosisPost-essential Thrombocythemia Myelofibrosis+3 more
Prelude Therapeutics100 enrolled5 locationsNCT07469891
Recruiting
Phase 1Phase 2
Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis
Myeloproliferative Neoplasms (MPN)Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)Essential Thrombocythemia, ET
Jubilant Therapeutics Inc.30 enrolled7 locationsNCT07612280
Not Yet Recruiting
Phase 1
A Dose finding Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of ZE74-0282 in Select JAK2 V617F Mutated Hematologic Disorders
Myeloproliferative Neoplasms (MPNs)
Eilean Therapeutics AU Pty Ltd (A subsidiary of Eilean Therapeutics LLC)60 enrolled2 locationsACTRN12626000638336
Recruiting
Phase 1Phase 2
Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes Overlap Syndromes (ABNL-MARRO)
MDS/MPN
Michael Savona94 enrolled4 locationsNCT04061421
Recruiting
Phase 1Phase 2
An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms
MyelofibrosisMyeloproliferative NeoplasmPolycythemia Vera+2 more
University of California, Irvine27 enrolled2 locationsNCT05123365
Not Yet Recruiting
Phase 1
A Double-Blind, Placebo-Controlled, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZE74-0282 in Healthy Volunteers.
Myeloproliferative Neoplasms (MPN)
Eilean Therapeutics AU Pty Ltd (A subsidiary of Eilean Therapeutics LLC)40 enrolled1 locationACTRN12626000214336
Recruiting
Phase 1Phase 2
SPEARHEAD-3 Pediatric Study
OsteosarcomaSynovial SarcomaMalignant Peripheral Nerve Sheath Tumor (MPNST)+1 more
USWM CT, LLC20 enrolled10 locationsNCT05642455
Recruiting
Phase 1
Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm
MyelofibrosisEssential ThrombocythemiaMPN
Marina Kremyanskaya10 enrolled1 locationNCT05025488