Mpox Clinical Trials

2 recruiting

Mpox Trials at a Glance

9 actively recruiting trials for mpox are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Phase 2 with 3 trials, with the heaviest enrollment activity in Kinshasa, Belo Horizonte, and Boende. Lead sponsors running mpox studies include Institute of Tropical Medicine, Belgium, BioNTech SE, and Bavarian Nordic.

Browse mpox trials by phase

Treatments under study

About Mpox Clinical Trials

Looking for clinical trials for Mpox? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mpox trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mpox clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 19 of 9 trials

Recruiting
Phase 2

A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity After Immunization With an mRNA-based Mpox Vaccine Candidate in Africa

Mpox (Monkeypox)
BioNTech SE310 enrolled6 locationsNCT07379580
Recruiting

Investigating MPXV Viral Clearance in Mpox Cases and Secondary Attack Rate in Contacts

Mpox (Monkeypox)
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia550 enrolled1 locationNCT07267390
Recruiting
Phase 2

Comparability Trial of the MVA-BN Vaccine Manufactured in Different Production Cells

Monkeypox (Mpox)
Bavarian Nordic744 enrolled10 locationsNCT07199569
Recruiting
Phase 3

Phase 3 Infant Safety & Immunogenicity Trial of MVA-BN® in DRC

SafetyVaccinationChildren+3 more
Jean-Pierre Van geertruyden344 enrolled1 locationNCT06844487
Recruiting
Phase 2

An Immunogenicity and Safety Trial of MVA-BN in Adults Living With HIV for the Prevention of Mpox Infection, in Kinshasa, DRC

Mpox (Monkeypox)
Institute of Tropical Medicine, Belgium600 enrolled1 locationNCT06839989
Recruiting

Epidemiological and Pathophysiological Insights Through a Cross-sectional Survey (EPIC)

Monkeypox (Mpox)
Institute of Tropical Medicine, Belgium1,000 enrolled2 locationsNCT06840860
Recruiting
Phase 3

Assessment of the Efficacy and Safety of Tecovirimat in Patients With Monkeypox Virus Disease

MonkeypoxMpox
ANRS, Emerging Infectious Diseases480 enrolled12 locationsNCT05597735
Recruiting
Not Applicable

Mpox Comprehensive Assessment for Responsive Immunisation in Emergency Outbreaks

Mpox
University of Birmingham650 enrolled1 locationNCT06887556
Recruiting

Looking for Asymptomatic Mpox in a Population at High Risk

Mpox (Monkeypox)
Unity Health Toronto450 enrolled1 locationNCT06353737