Early Phase 1 Mutation Clinical Trials

5 recruitingEarly Phase 1

What is a Early Phase 1 trial?

Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.

Showing 1–5 of 5 trials

Recruiting

Early Phase 1

Window of Opportunity Study of DSP-0390 in Gliomas

Glioma, MalignantIDH Mutation

Washington University School of Medicine20 enrolled1 locationNCT06636162

Recruiting

Early Phase 1

A Trial to Evaluate CSF ctDNA and Safety of Plixorafenib Alone or With Retifanlimab in Patients With BRAF-altered Glioma

BRAF V600E Mutation

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins24 enrolled1 locationNCT06610682

Recruiting

Early Phase 1

Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma

Melanoma Stage IVBRAF V600 MutationMelanoma Stage III

H. Lee Moffitt Cancer Center and Research Institute50 enrolled1 locationNCT04741997

Recruiting

Early Phase 1

177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors

PDL1 Gene Mutation

Radiopharm Theranostics, Ltd30 enrolled5 locationsNCT06305962

Recruiting

Early Phase 1

HEAT Trial (HER2 Antibody Therapy With Lutetium-177)

Advanced Solid TumorsHER2 Gene Mutation

Radiopharm Theranostics, Ltd30 enrolled5 locationsNCT06824155