Window of Opportunity Study of DSP-0390 in Gliomas

This study tests a new drug called DSP-0390 in people who have a type of brain tumor called a glioma — specifically lower-grade or recurring gliomas with a particular genetic change (IDH mutation). The drug is given before surgery so researchers can study how it affects tumor tissue. **You may be eligible if...** - You are 18 or older with a suspected or confirmed lower-grade or recurring IDH-mutant glioma - You are scheduled for brain surgery to remove or biopsy the tumor - Your blood counts, liver, and kidney function are within acceptable ranges - You are in generally good health (able to perform most daily activities) **You may NOT be eligible if...** - You have received bevacizumab (an anti-cancer drug) in the past 3 months - Your tumor has spread to multiple areas of the brain or outside the brain - You have a serious heart condition or abnormal heart rhythm - You are pregnant or breastfeeding - You are currently on certain medications that interact with the study drug (e.g., carbamazepine, phenytoin) - You have active hepatitis B or C Talk to your doctor to see if this trial is right for you.