Phase 1 NF1 Clinical Trials

5 recruitingPhase 1

What is a Phase 1 trial?

Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.

Showing 1–5 of 5 trials

Recruiting

Phase 1Phase 2

Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF).

NF1Cutaneous NeurofibromaMonotherapy

Johns Hopkins University24 enrolled1 locationNCT06159166

Recruiting

Phase 1

A Study of Avutometinib for People With Solid Tumor Cancers

Solid TumorSolid Tumor, AdultNeuroblastoma+12 more

Memorial Sloan Kettering Cancer Center23 enrolled2 locationsNCT06104488

Recruiting

Phase 1

Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1

NeurofibromatosisNF1Cutaneous Neurofibroma+3 more

Johns Hopkins University10 enrolled1 locationNCT07102394

Recruiting

Phase 1

PAS-004 in Adults Who Have Neurofibromatosis Type 1 With Plexiform Neurofibromas

NF1 Mutation

Pasithea Therapeutics Corp.56 enrolled5 locationsNCT06961565

Recruiting

Phase 1

PAS-004 in Patients With Advanced Solid Tumors

Advanced Solid TumorsRAS MutationNF1 Mutation+1 more

Pasithea Therapeutics Corp.48 enrolled7 locationsNCT06299839