Phase 1 Open Clinical Trials
50 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 50 trials
Recruiting
Phase 1
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
Antiphospholipid Syndrome (APS)Immune-mediated Necrotizing Myopathy (IMNM)Immune Thrombocytopenia (ITP)+3 more
Chugai Pharmaceutical144 enrolled77 locationsNCT06371417
Recruiting
Phase 1Phase 2
Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease
Immune Thrombocytopenic PurpuraITP - Immune ThrombocytopeniaWarm Autoimmune Hemolytic Anemia+1 more
CRISPR Therapeutics AG60 enrolled8 locationsNCT07549698
Recruiting
Phase 1
OM336 in Autoimmune Cytopenias
ITP - Immune ThrombocytopeniaAIHA - Warm Autoimmune Hemolytic AnemiaAIHA - Cold Autoimmune Hemolytic Anemia
Lakefront Biotherapeutics West LLC32 enrolled3 locationsNCT07083960
Recruiting
Phase 1Phase 2
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
NeutropeniaInfectionsWarts+2 more
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled1 locationNCT00967785
Recruiting
Phase 1Phase 2
A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia
Immune Thrombocytopenia (ITP)
Eli Lilly and Company68 enrolled45 locationsNCT06721013
Recruiting
Phase 1
RN1201 Injection in the Treatment of Antibody-Mediated Diseases
Refractory Immune-mediated Platelet Transfusion RefractorinessRelapsed or Refractory Immune Thrombocytopenia
The First Affiliated Hospital of Soochow University9 enrolled1 locationNCT07072247
Recruiting
Phase 1
Study of LGW16-03 To Identify Nerves
AdultsOpen-field SurgeryMajor Nerve
Eric R. Henderson38 enrolled1 locationNCT07385430
Recruiting
Phase 1
IASO-782 in Autoimmune Hematological Diseases
Autoimmune ThrombocytopeniaWarm Autoimmune Haemolytic Anaemia
Shanghai IASO Biotechnology Co., Ltd16 enrolled2 locationsNCT06534021
Recruiting
Phase 1
Phase I Study of SHR-2173 Injection in Patients With Primary Immune Thrombocytopenia
Immune Thrombocytopenia
Guangdong Hengrui Pharmaceutical Co., Ltd10 enrolled1 locationNCT07206758
Recruiting
Phase 1
Safety and Efficacy of GL-2045 in Patients With Immune Thrombocytopenia
Immune Thrombocytopenia
Gliknik Inc.42 enrolled1 locationNCT07605845
Recruiting
Phase 1
Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)
Open-angle Glaucoma (OAG)NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
Life Biosciences Inc.18 enrolled4 locationsNCT07290244
Recruiting
Phase 1Phase 2
JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure
Severe Aplastic AnemiaSingle Lineage Cytopenias, T-LGLHypoplastic MDS
National Heart, Lung, and Blood Institute (NHLBI)145 enrolled1 locationNCT05998408
Recruiting
Phase 1Phase 2
GVB-2001 Gene Therapy Via Intracameral Injection for the Treatment of Primary Open Angle Glaucoma
Primary Open Angle Glaucoma (POAG)
IVIEW Therapeutics Inc.6 enrolled1 locationNCT06921317
Recruiting
Phase 1
Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)
Idiopathic CD4 Lymphopenia
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled1 locationNCT04097561
Recruiting
Phase 1
A Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma
Advanced Urothelial CarcinomaOral Drug AdministrationOpen Label
Flare Therapeutics Inc.120 enrolled12 locationsNCT05929235
Recruiting
Phase 1
Dose Dense Rituximab for High Risk Newly Diagnosed Acute Immune Thrombocytopenic Purpura
Immune Thrombocytopenic Purpura
New York Medical College20 enrolled1 locationNCT04323748
Recruiting
Phase 1
Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia
Osteopenia
Tufts Medical Center60 enrolled1 locationNCT07473713
Recruiting
Phase 1Phase 2
A Phase 1b/2a Study of Budoprutug in Subjects With Immune Thrombocytopenia (ITP)
ITPImmune Thrombocytopenia (ITP)Monoclonal+2 more
Climb Bio, Inc.24 enrolled20 locationsNCT07043946
Recruiting
Phase 1Phase 2
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
Open Angle GlaucomaOcular Hypertension
AbbVie96 enrolled49 locationsNCT04499248
Recruiting
Phase 1Phase 2
A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia
Idiopathic CD4 Lymphopenia
National Institute of Allergy and Infectious Diseases (NIAID)60 enrolled1 locationNCT05600920