Opioid Withdrawal Clinical Trials

9 recruitingLast updated: May 29, 2026

There are 9 actively recruiting opioid withdrawal clinical trials across 3 countries. Studies span Phase 2, Not Applicable, Phase 1. Top locations include Baltimore, Maryland, United States, Birmingham, Alabama, United States, Burlington, Vermont, United States. Updated daily from ClinicalTrials.gov.


Opioid Withdrawal Trials at a Glance

9 actively recruiting trials for opioid withdrawal are listed on ClinicalTrialsFinder across 6 cities in 3 countries. The largest study group is Phase 2 with 3 trials, with the heaviest enrollment activity in Baltimore, Birmingham, and Burlington. Lead sponsors running opioid withdrawal studies include University of Maryland, Baltimore, Milton S. Hershey Medical Center, and Medical University of South Carolina.

Browse opioid withdrawal trials by phase

Treatments under study

About Opioid Withdrawal Clinical Trials

Looking for clinical trials for Opioid Withdrawal? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Opioid Withdrawal trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Opioid Withdrawal clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 19 of 9 trials

Recruiting
Phase 2

Evaluating Buspirone to Treat Opioid Withdrawal

AnxietyOpioid-use DisorderOpioid Withdrawal+1 more
University of Maryland, Baltimore100 enrolled1 locationNCT05511909
Recruiting

Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

Opioid-use DisorderOpioid Withdrawal
Spark Biomedical, Inc.20 enrolled2 locationsNCT06487533
Recruiting

CEDRN: Opioid Registry

Opioid-use DisorderOpioid WithdrawalPolysubstance Abuse+2 more
University of British Columbia7,200 enrolled1 locationNCT07466784
Recruiting

Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome

Neonatal Opioid Withdrawal Syndrome
HELP for NOWS Consortium796 enrolled22 locationsNCT07278375
Recruiting

MicroRNA Biomarkers for Neonatal Opioid Withdrawal Syndrome

Neonatal Abstinence SyndromeNeonatal Opioid Withdrawal Syndrome
Milton S. Hershey Medical Center50 enrolled1 locationNCT05937594
Recruiting
Phase 1Phase 2

ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain

Chronic PainOpioid Withdrawal
Medical University of South Carolina240 enrolled1 locationNCT06442566
Recruiting
Phase 2

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

Opioid-use DisorderOpioid WithdrawalOpioid Craving
University of Maryland, Baltimore60 enrolled1 locationNCT05027919
Recruiting
Not Applicable

Evaluation of a Physical Device for Medical Use (ADTPM 1) for Opioid Withdrawal Symptoms

Opioid-use DisorderOpioid Withdrawal (Disorder)
Nu Eyne Co., Ltd.24 enrolled1 locationNCT07079215
Recruiting
Not Applicable

Understanding the Effects of Transcutaneous Auricular Neurostimulation for Treatment of Chronic Pain

AnalgesiaOpioid Withdrawal
The University of Texas Medical Branch, Galveston60 enrolled1 locationNCT05555485