Chronic Pain Clinical Trials

289 recruiting

Chronic Pain Trials at a Glance

267 actively recruiting trials for chronic pain are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Not Applicable with 167 trials, with the heaviest enrollment activity in Boston, Chicago, and Houston. Lead sponsors running chronic pain studies include VA Office of Research and Development, University of Minnesota, and Massachusetts General Hospital.

Browse chronic pain trials by phase

Treatments under study

About Chronic Pain Clinical Trials

Looking for clinical trials for Chronic Pain? There are currently 289 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 267 trials

Recruiting
Phase 2

Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal

Chronic PainDrug Dependence of Morphine TypeSymptom, Withdrawal
University of Calgary40 enrolled1 locationNCT04939623
Recruiting
Not Applicable

Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial

Musculoskeletal PainChronic PainFibromyalgia
G. d'Annunzio University44 enrolled2 locationsNCT07048366
Recruiting
Not Applicable

Reducing Opioid Use for Chronic Pain Patients Following Surgery

Opioid UsePostoperative PainChronic Pain+1 more
University Health Network, Toronto210 enrolled1 locationNCT03675386
Recruiting

Interoceptive Awareness and Function in Adolescents With Chronic Pain

Pain, ChronicChronic PainChronic Pain Syndrome
Connecticut Children's Medical Center49 enrolled1 locationNCT07325110
Recruiting
Not Applicable

Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain

Chronic Pain
Arizona State University10 enrolled2 locationsNCT06947122
Recruiting
Not Applicable

A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

MastectomyBreastChronic Pain
University of Chicago8 enrolled1 locationNCT06382272
Recruiting
Phase 4

Dex & Mastectomy Pain

Post-Mastectomy Chronic Pain Syndrome
McGill University Health Centre/Research Institute of the McGill University Health Centre170 enrolled1 locationNCT07556952
Recruiting
Not Applicable

Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial

Chronic PainChildhood Cancer Survivor
St. Jude Children's Research Hospital228 enrolled1 locationNCT07160621
Recruiting
Not Applicable

RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain

Sleep DisturbanceChronic Pain
VA Office of Research and Development160 enrolled2 locationsNCT05963607
Recruiting

Outpatient Midline Catheter in Patients Receiveing Lidocaine Infusion Series.

Chronic PainOutpatientLidocaine Infusion+1 more
Medical University of Warsaw500 enrolled1 locationNCT07555314
Recruiting
Phase 4

Stanford Pragmatic Effectiveness Comparison

Chronic Pain
Stanford University450 enrolled1 locationNCT04441034
Recruiting
Not Applicable

Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain

Opioid UseChronic InsomniaChronic Pain
University of South Florida165 enrolled1 locationNCT06345872
Recruiting
Not Applicable

POP SINGER Pilot Study

Chronic Pain
University Hospitals Cleveland Medical Center24 enrolled1 locationNCT07450131
Recruiting
Not Applicable

Enhancing Health in Rural Populations: Music as Therapy

StressChronic PainDepression Disorder+1 more
Northern Arizona University60 enrolled2 locationsNCT07538427
Recruiting

SPACE for Youth With Chronic Pain

Chronic Pain
Children's Hospital of Philadelphia48 enrolled2 locationsNCT07425691
Recruiting
Early Phase 1

Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain

Chronic PainChronic Pancreatitis
Medical University of South Carolina48 enrolled1 locationNCT06205342
Recruiting
Not Applicable

Reaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention - UH3

Chronic Pain
Minneapolis Veterans Affairs Medical Center500 enrolled1 locationNCT07541599
Recruiting
Not Applicable

Reboot Pain (tDCS)

Chronic Pain
Emory University100 enrolled1 locationNCT07411859
Recruiting
Not Applicable

Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment

Chronic PainOpioid-use Disorder
Albert Einstein College of Medicine123 enrolled1 locationNCT05039554
Recruiting
Not Applicable

Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

Chronic Low-back PainChronic PainLow Back Pain+1 more
Boston Scientific Corporation70 enrolled7 locationsNCT07190807