Chronic Pain Clinical Trials

301 recruitingLast updated: June 17, 2026

There are 301 actively recruiting chronic pain clinical trials across 35 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Chicago, Illinois, United States, Boston, Massachusetts, United States, Baltimore, Maryland, United States. Updated daily from ClinicalTrials.gov.


Chronic Pain Trials at a Glance

301 actively recruiting trials for chronic pain are listed on ClinicalTrialsFinder across 6 cities in 35 countries. The largest study group is Not Applicable with 190 trials, with the heaviest enrollment activity in Chicago, Boston, and Baltimore. Lead sponsors running chronic pain studies include VA Office of Research and Development, University of Minnesota, and Massachusetts General Hospital.

Browse chronic pain trials by phase

Treatments under study

About Chronic Pain Clinical Trials

Looking for clinical trials for Chronic Pain? There are currently 320 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 301 trials

Recruiting

Emotional Intelligence and Chronic Orofacial Pain

Chronic Pain
University Hospital, Brest88 enrolled1 locationNCT07280338
Recruiting
Phase 3

Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children

Chronic PainNeuropathic Pain
University Hospital, Brest46 enrolled10 locationsNCT05997979
Recruiting
Phase 2

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Post Operative PainChronic PainKnee Pain Chronic
University Health Network, Toronto400 enrolled3 locationsNCT06123715
Recruiting
Not Applicable

Integrated PTSD and Chronic Pain Treatment

Chronic PainPTSD
Weill Medical College of Cornell University20 enrolled1 locationNCT07225049
Recruiting
Not Applicable

Conditioned Open-label Placebos to Facilitate Opioid Reduction in Patients With Subacute or Chronic Pain Pain: a Randomized Controlled Trial

Chronic PainSubacute Pain
Cosima Locher86 enrolled1 locationNCT06350786
Recruiting

Photobiomodulation for Chronic Pain and Fatigue in Hypermobile Ehlers-Danlos Syndrome (PBM-SEDh-01)

Chronic PainFatigue Syndrome, ChronicEhlers-Danlos Syndrome, Hypermobile
Centre Medical ISM (Integrative Systemic Medicine)25 enrolled1 locationNCT07637084
Recruiting
Not Applicable

Assessing Chronic Pain Patient Preferences

Chronic Pain
Université Catholique de Louvain200 enrolled1 locationNCT07453524
Recruiting

ARPA-H Smart Band-Aid to Measure Chronic Pain in Women

Chronic Pain
Northwestern University115 enrolled2 locationsNCT06994988
Recruiting

Patient Retrospective Outcomes (PRO)

Chronic Pain
Boston Scientific Corporation15,000 enrolled144 locationsNCT01550575
Recruiting
Not Applicable

Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial

Chronic PainChildhood Cancer Survivor
St. Jude Children's Research Hospital228 enrolled1 locationNCT07160621
Recruiting
Not Applicable

Culturally Adapted Pain Management for Indigenous Peoples

Chronic Pain
University of California, San Diego30 enrolled1 locationNCT07524751
Recruiting
Not Applicable

Group-based Integrative Pain Management in Primary Care Safety Net Clinics

Chronic Pain
University of California, San Francisco360 enrolled1 locationNCT06327542
Recruiting
Not Applicable

Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients

Depression - Major Depressive DisorderChronic PainFibromyalgia
Hospital Ambroise Paré Paris36 enrolled1 locationNCT07642882
Recruiting
Not Applicable

Virtual Intelligence for Transformative Lifestyle Solutions in Pain

Chronic Pain
Montefiore Medical Center15 enrolled1 locationNCT07124598
Recruiting
Not Applicable

Video Intervention for Older Adults With Chronic Pain

Musculoskeletal PainChronic PainOlder Adults With Chronic Pain
Butler Hospital100 enrolled1 locationNCT07404618
Recruiting
Not Applicable

Equipping Patients Using Interventions for Pain and Depression

DepressionMusculoskeletal PainChronic Pain+1 more
Indiana University304 enrolled1 locationNCT06500780
Recruiting
Not Applicable

Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

Chronic leg painLeg painChronic Low-back Pain+3 more
Boston Scientific Corporation70 enrolled7 locationsNCT07190807
Recruiting
Phase 1

Managing Chronic Tendon Pain by Metformin

Chronic PainAchilles tendinopathyTendinopathy
James Wang40 enrolled1 locationNCT06100822
Recruiting
Phase 4

Dex & Mastectomy Pain

Post-Mastectomy Chronic Pain Syndrome
McGill University Health Centre/Research Institute of the McGill University Health Centre170 enrolled1 locationNCT07556952
Recruiting
Not Applicable

The PROACTIVE Study for Black Elders

Pain, ChronicMusculoskeletal PainChronic Pain+2 more
University of Florida120 enrolled1 locationNCT06512727