Phase 1 Oral Clinical Trials
30 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 30 trials
Recruiting
Phase 1Phase 2
FACE Phase II (a Stage II Trial)
MCIMild Behavioral ImpairmentSubjective Cognitive Decline (SCD)
Stanford University80 enrolled1 locationNCT07130669
Recruiting
Phase 1
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
Locally Advanced Head and Neck Squamous Cell CarcinomaClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Stage III Hypopharyngeal Carcinoma AJCC v8+23 more
National Cancer Institute (NCI)46 enrolled18 locationsNCT05172245
Recruiting
Phase 1
A Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma
Advanced Urothelial CarcinomaOral Drug AdministrationOpen Label
Flare Therapeutics Inc.120 enrolled12 locationsNCT05929235
Recruiting
Phase 1Phase 2
Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC)
Oral Cavity Squamous Cell Carcinoma
University of California, San Francisco40 enrolled1 locationNCT06097468
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
Frontotemporal DementiaFTDDementia, Frontotemporal+1 more
AviadoBio Ltd18 enrolled19 locationsNCT06064890
Recruiting
Phase 1Phase 2
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
Mesial Temporal Lobe Epilepsy
UniQure Biopharma B.V.12 enrolled18 locationsNCT06063850
Recruiting
Phase 1
Pharmacokinetics of Sulopenem Etzadroxil Plus Probenecid in Adolescents
Pharmacokinetics After Oral Intake
Iterum Therapeutics, International Limited12 enrolled1 locationNCT07092813
Recruiting
Phase 1
Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage Cancer
SafetyDemoralization
Gustavo Vazquez15 enrolled1 locationNCT06818994
Recruiting
Phase 1Phase 2
Topical Imiquimod Treatment of Oral Dysplasia
Oral Dysplasia
University of Southern California20 enrolled1 locationNCT07210775
Recruiting
Phase 1
TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer
Metastatic Head and Neck Squamous Cell CarcinomaStage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8Recurrent Head and Neck Squamous Cell Carcinoma+20 more
Emory University40 enrolled2 locationsNCT06868433
Recruiting
Phase 1
Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders
Temporal Interference StimulationHealth AdultsSafety and Effectiveness+1 more
Taipei Veterans General Hospital, Taiwan80 enrolled1 locationNCT07179848
Recruiting
Phase 1
Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer
Locally Recurrent Head and Neck Squamous Cell CarcinomaRecurrent Laryngeal Squamous Cell CarcinomaRecurrent Oral Cavity Squamous Cell Carcinoma+3 more
Ohio State University Comprehensive Cancer Center45 enrolled1 locationNCT04754321
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
Epilepsy, Temporal Lobe
Neurona Therapeutics10 enrolled17 locationsNCT06422923
Recruiting
Phase 1Phase 2
A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
Frontotemporal DementiaFTDFTD-GRN
Passage Bio, Inc.30 enrolled10 locationsNCT04747431
Recruiting
Phase 1
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909
Recruiting
Phase 1
Single Ascending Dose and Multiple Ascending Dose Evaluation of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MDI-2517 in Healthy Participants
Safety After Oral Intake
MDI Therapeutics, Inc.52 enrolled1 locationNCT07220889
Recruiting
Phase 1
Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1
Transfemoral Amputation
North Carolina State University24 enrolled1 locationNCT07204925
Recruiting
Phase 1
Fenretinide Mucoadhesive Patch: Evaluation of Oral Cancer Prevention Efficacy in Adults With Premalignant Oral Lesions.
Oral LeukoplakiaOral Dysplasia
Ohio State University25 enrolled1 locationNCT07149220
Recruiting
Phase 1
Pharmacokinetics and Pharmacodynamics of CHI-914 in Healthy Participants
Behavioral Pharmacology of Cannabis
Johns Hopkins University30 enrolled1 locationNCT05324982
Recruiting
Phase 1Phase 2
RAPA-201 Therapy of Solid Tumors
Head and Neck CancerEsophageal Squamous Cell CarcinomaSolid Tumor+6 more
Rapa Therapeutics LLC37 enrolled1 locationNCT05144698