Oral Clinical Trials

655 recruitingLast updated: June 18, 2026

There are 655 actively recruiting oral clinical trials across 63 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include New York, New York, United States, Chicago, Illinois, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Oral Trials at a Glance

655 actively recruiting trials for oral are listed on ClinicalTrialsFinder across 6 cities in 63 countries. The largest study group is Not Applicable with 325 trials, with the heaviest enrollment activity in New York, Chicago, and Houston. Lead sponsors running oral studies include National Cancer Institute (NCI), M.D. Anderson Cancer Center, and Cairo University.

Treatments under study

About Oral Clinical Trials

Looking for clinical trials for Oral? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Oral trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Oral clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 655 trials

Recruiting
Phase 2Phase 3

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell CarcinomaStage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7+6 more
National Cancer Institute (NCI)613 enrolled342 locationsNCT01810913
Recruiting
Phase 2

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell CarcinomaStage III Hypopharyngeal Carcinoma AJCC v8Stage III Laryngeal Cancer AJCC v8+13 more
ECOG-ACRIN Cancer Research Group189 enrolled676 locationsNCT02734537
Recruiting
Not Applicable

Moral Injury in French Healthcare Workers

Moral Injury
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer3,073 enrolled1 locationNCT06926296
Recruiting
Not Applicable

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia

Skin CancerMucosal Neoplasm of Oral CavitySoft Tissue Neoplasm
Alpha Tau Medical LTD.56 enrolled1 locationNCT04534127
Recruiting

MRI Study of Musculoskeletal Function

Patellofemoral Pain SyndromeAbnormalitiesImaging
National Institutes of Health Clinical Center (CC)750 enrolled1 locationNCT00051857
Recruiting

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic Lateral SclerosisFrontotemporal DementiaProgressive Supranuclear Palsy
National Institute of Neurological Disorders and Stroke (NINDS)360 enrolled1 locationNCT03225144
Recruiting
Phase 2

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

DepressionDepressive DisorderMolecular Mechanisms of Pharmacological Action+10 more
National Institute of Mental Health (NIMH)50 enrolled1 locationNCT06511908
Recruiting
Phase 2

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Locally Recurrent Head and Neck Squamous Cell CarcinomaLocally Recurrent Hypopharyngeal Squamous Cell Carcinoma+15 more
National Cancer Institute (NCI)180 enrolled70 locationsNCT07195734
Recruiting

Spectroscopic Analysis of Tongue Tumor Samples.

Squamous Cell CarcinomaOral CavityMass Spectroscopy+3 more
Centre Hospitalier Universitaire, Amiens33 enrolled1 locationNCT05104619
Recruiting

Valvular Aortic Stenosis Prognosis Study

Morality
Centre Hospitalier Universitaire, Amiens3,450 enrolled1 locationNCT03628313
Recruiting
Not Applicable

Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.

Facial asymmetryOral Squamous Cell CarcinomaMucormycosis+3 more
Tishreen University30 enrolled1 locationNCT07654647
Recruiting

Clinical Procedures to Support Research in ALS

Amyotrophic Lateral SclerosisPrimary Lateral SclerosisProgressive Muscular Atrophy+1 more
University of Miami1,200 enrolled11 locationsNCT03489278
Recruiting
Phase 1

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

Unresectable Head and Neck Squamous Cell CarcinomaStage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8+27 more
National Cancer Institute (NCI)39 enrolled1 locationNCT07156227
Recruiting
Phase 2

Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage.

Patellofemoral osteoarthritis
University Hospital, Basel, Switzerland75 enrolled9 locationsNCT06163573
Recruiting
Phase 2

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell CarcinomaRecurrent Oropharyngeal Squamous Cell CarcinomaRecurrent Hypopharyngeal Squamous Cell Carcinoma+2 more
National Cancer Institute (NCI)188 enrolled178 locationsNCT04671667
Recruiting

Biospecimen Procurement for Head and Neck Disorders

Head and Neck NeoplasmsLaryngeal DiseaseHearing Disorder+2 more
National Cancer Institute (NCI)1,000 enrolled9 locationsNCT03429036
Recruiting
Phase 3

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Metastatic Head and Neck Squamous Cell CarcinomaStage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8Recurrent Head and Neck Squamous Cell Carcinoma+18 more
National Cancer Institute (NCI)158 enrolled177 locationsNCT06589804
Recruiting

Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Primary Hip Prosthesis System

Osteoarthritis (OA) of the hipTotal Hip Arthroplasty (THA)Joint Diseases+2 more
TIPMED Medical Device Manufacturing Ltd. Co.101 enrolled4 locationsNCT07651735
Recruiting
Phase 2

Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus

Oral Lichen Planus
Cairo University42 enrolled1 locationNCT06981767
Recruiting
Not Applicable

The Effect of Different Flap Closure Techniques on Postoperative Morbidity in Impacted Third Molar Surgery

Impacted Mandibular Third MolarOral Surgerypostoperative morbidity
Recep Tayyip Erdogan University148 enrolled1 locationNCT07198282