Oral Clinical Trials

2 recruiting

Oral Trials at a Glance

574 actively recruiting trials for oral are listed on ClinicalTrialsFinder across 6 cities in 58 countries. The largest study group is Not Applicable with 286 trials, with the heaviest enrollment activity in Chicago, Houston, and New York. Lead sponsors running oral studies include M.D. Anderson Cancer Center, Cairo University, and National Cancer Institute (NCI).

Treatments under study

About Oral Clinical Trials

Looking for clinical trials for Oral? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Oral trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Oral clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 574 trials

Recruiting
Phase 2

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Locally Recurrent Head and Neck Squamous Cell CarcinomaLocally Recurrent Hypopharyngeal Squamous Cell Carcinoma+15 more
National Cancer Institute (NCI)180 enrolled40 locationsNCT07195734
Recruiting

A Natural History Study of Bone and Mineral Disorders

Tumor Induced OsteomalciaOsteomalaciaFamilial Tumoral Calcinosis
National Institute of Dental and Craniofacial Research (NIDCR)1,000 enrolled1 locationNCT00024804
Recruiting
Phase 2

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic Head and Neck Squamous Cell Carcinoma+22 more
National Cancer Institute (NCI)150 enrolled221 locationsNCT05136196
Recruiting

The Neurodevelopmental and Behavioral Phenotyping Screening Protocol

AutismNeurologic DisordersNeurodegenerative Disease+1 more
National Institute of Mental Health (NIMH)5,000 enrolled1 locationNCT00271622
Recruiting
Phase 2Phase 3

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell CarcinomaStage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7+6 more
National Cancer Institute (NCI)613 enrolled341 locationsNCT01810913
Recruiting
Phase 2

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell CarcinomaRecurrent Oropharyngeal Squamous Cell CarcinomaRecurrent Hypopharyngeal Squamous Cell Carcinoma+2 more
National Cancer Institute (NCI)188 enrolled177 locationsNCT04671667
Recruiting

Biospecimen Procurement for Head and Neck Disorders

Head and Neck NeoplasmsLaryngeal DiseaseHearing Disorder+2 more
National Cancer Institute (NCI)1,000 enrolled9 locationsNCT03429036
Recruiting

Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

Healthy ChildrenChildren With Neurodevelopmental DisordersChildren With Neuropsychiatric Disorders+1 more
National Institute of Mental Health (NIMH)244 enrolled5 locationsNCT04639830
Recruiting
Phase 3

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Metastatic Head and Neck Squamous Cell CarcinomaStage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8Recurrent Head and Neck Squamous Cell Carcinoma+18 more
National Cancer Institute (NCI)158 enrolled176 locationsNCT06589804
Recruiting

Natural History of Depression, Bipolar Disorder and Suicide Risk

Molecular Mechanisms of Pharmacological ActionDepressive SymptomsSuicide+17 more
National Institute of Mental Health (NIMH)500 enrolled1 locationNCT06462196
Recruiting
Phase 2

A Study of LY4515100 in Participants With Pain Following Third Molar Removal

Acute PainMolar, ThirdMolar+1 more
Eli Lilly and Company212 enrolled1 locationNCT07511816
Recruiting
Not Applicable

Photobiomodulation, Photodynamic Therapy, and Clobetasol in the Treatment of Oral Lichen Planus.

Oral Lichen PlanusErosive Lichen PlanusMucosal Lesions
Medical University of Silesia60 enrolled1 locationNCT07278999
Recruiting

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic Lateral SclerosisFrontotemporal DementiaProgressive Supranuclear Palsy
National Institute of Neurological Disorders and Stroke (NINDS)360 enrolled1 locationNCT03225144
Recruiting
Not Applicable

Effects of Probiotics in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Spectrum Disorder (ALS-FTDSD) Patients

ALS (Amyotrophic Lateral Sclerosis)ALSFTDFrontal Temporal Dementia (FTD)
Centre hospitalier de l'Université de Montréal (CHUM)150 enrolled1 locationNCT06051123
Recruiting
Not Applicable

Develop and Evaluate An Artificial Intelligence Assisted Prehabilitation Program for Returning to Work and Cost-effectiveness Analysis in Patients With Oral Cancer

PhysiotherapyQuality of LifePrehabilitation+7 more
Taipei Veterans General Hospital, Taiwan650 enrolled5 locationsNCT07562100
Recruiting
Not Applicable

Effect of Apiban Therapy on AVF Maturation in ESRD Patients

Direct Oral Anticoagulants (DOACs)Arterio-venous Fistula, Maturation, Chronic Kidney DiseaseEndstage Renal Disease
Combined military hospital lahore190 enrolled1 locationNCT07559942
Recruiting
Not Applicable

TIS for NSSI in Adolescent Depression

Temporal Interference StimulationMajor Depressive DisorderNon Suicidal Self Injury
The Second Hospital of Anhui Medical University60 enrolled1 locationNCT07554755
Recruiting
Phase 2

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population

Head and Neck CancerOropharynx CancerHypopharynx Cancer+3 more
Mayo Clinic25 enrolled1 locationNCT06997068
Recruiting
Phase 2

Lysergic Acid Diethylamide (LSD) in Palliative Care

PainQuality of LifePsychological Distress+7 more
University Hospital, Basel, Switzerland60 enrolled4 locationsNCT05883540
Recruiting

Changes in Attentional Control After a Focal Seizure.

Temporal Lobe EpilepsyFrontal Lobe EpilepsyOthers Subtypes
University Hospital, Lille100 enrolled1 locationNCT06466681