Phase 1 Pleural Effusion Clinical Trials
10 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–10 of 10 trials
Recruiting
Phase 1Phase 2
First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion
Non-small Cell Lung CancerMalignant Pleural Effusions (Mpe)
Gang Hou105 enrolled1 locationNCT07332858
Recruiting
Phase 1Phase 2
A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC
NSCLC Stage IVMalignant Pleural Effusions
Wuhan YZY Biopharma Co., Ltd.96 enrolled1 locationNCT05543330
Recruiting
Phase 1
Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors
Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)10 enrolled1 locationNCT07443020
Recruiting
Phase 1
Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease
Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
David Bartlett, MD10 enrolled1 locationNCT07192900
Recruiting
Phase 1
Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer
Malignant Pleural EffusionMalignant ascites
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)12 enrolled1 locationNCT06016179
Recruiting
Phase 1
A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion
Malignant Pleural Effusions (Mpe)
Jemincare30 enrolled1 locationNCT06740019
Recruiting
Phase 1
A Study of MT027 in Patients with Pleural Malignant Tumors
Malignant Pleural EffusionAdvanced Malignant Solid TumorPleural Metastases+3 more
Suzhou Maximum Bio-tech Co., Ltd.18 enrolled1 locationNCT06726564
Recruiting
Phase 1
OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.
Pleural CarcinomatosisQuality of LifeChemotherapy Effect+4 more
Odense University Hospital20 enrolled1 locationNCT06421610
Recruiting
Phase 1
IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites
Pleural Effusion, Malignant
Affiliated Hospital of Jiangnan University40 enrolled1 locationNCT05268172
Not Yet Recruiting
Phase 1
A double-blind, placebo controlled randomised study to assess the tolerability, safety, and preliminary efficacy of taurolidine-citrate lock solution (TauroLock™) in patients with recurrent pleural effusions requiring management with Indwelling Pleural Catheters for recurrent effusion drainage.
Recurrent pleural effusion
St John of God Midland Hospital18 enrolled1 locationACTRN12622001280796