Pleural Effusion Clinical Trials

17 recruiting

Pleural Effusion Trials at a Glance

39 actively recruiting trials for pleural effusion are listed on ClinicalTrialsFinder across 6 cities in 15 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Boston, Pittsburgh, and Beijing. Lead sponsors running pleural effusion studies include Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute), Beth Israel Deaconess Medical Center, and National University of Malaysia.

Browse pleural effusion trials by phase

Treatments under study

About Pleural Effusion Clinical Trials

Looking for clinical trials for Pleural Effusion? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pleural Effusion trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pleural Effusion clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 39 trials

Recruiting

Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases

PneumothoraxCOPDPneumonia+4 more
Assiut University700 enrolled1 locationNCT06983366
Recruiting
Not Applicable

DRAIN: DRainage in Acute Decompensated Heart faIlure With Pleural effusioNs

Congestive Heart Failure(CHF)Pleural Effusion Due to Congestive Heart Failure
Albany Medical College216 enrolled1 locationNCT07419360
Recruiting
Not Applicable

Confocal Laser Endomicroscopy Guided Medical Thoracoscopy for the Diagnosis of Pleural Disease

Pleural DiseasesPleural Effusion
China-Japan Friendship Hospital158 enrolled1 locationNCT06741839
Recruiting
Phase 1

Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors

Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)10 enrolled1 locationNCT07443020
Recruiting

Pleural Effusion Biomarkers in Lung Adenocarcinoma Patients

Lung AdenocarcinomaPleural EffusionBiomarkers
Fu Jen Catholic University100 enrolled1 locationNCT07012759
Recruiting
Not Applicable

Pleuroscopy First Versus Thoracentesis First in Patients With Suspected Malignant Pleural Effusions

CancerPleural Effusion
Icahn School of Medicine at Mount Sinai98 enrolled2 locationsNCT06892691
Recruiting
Not Applicable

Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna Trial

PneumothoraxPleural EffusionLung Injury+3 more
Hospital Israelita Albert Einstein1,470 enrolled1 locationNCT06686251
Recruiting
Phase 1

Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease

Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
David Bartlett, MD10 enrolled1 locationNCT07192900
Recruiting
Not Applicable

Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System

Pleural Effusion
Johns Hopkins University200 enrolled6 locationsNCT03831386
Recruiting
Not Applicable

16F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or Segmentectomy

PneumothoraxPleural Effusion
University Hospital, Basel, Switzerland124 enrolled1 locationNCT06958848
Recruiting
Not Applicable

Effect of Bubble Positive Expiratory Pressure and Segmental Breathing Versus Incentive Spirometry in Pleural Effusion

Pleural Effusion
Riphah International University40 enrolled1 locationNCT07248774
Recruiting
Not Applicable

Normal Saline Flushing With And Without Heparin Lock In Maintaining Small Bore Intercostal Chest Catheter (ICC) Patency

Pleural Effusion
National University of Malaysia40 enrolled1 locationNCT06314620
Recruiting
Not Applicable

Virtual Reality: Distraction During Small Bore Intercostal Chest Drain Insertion

Pleural Effusion
National University of Malaysia80 enrolled1 locationNCT06247800
Recruiting
Not Applicable

Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU

MesotheliomaAtelectasisPneumothorax+11 more
Brigham and Women's Hospital230 enrolled1 locationNCT06538376
Recruiting

UNC Pleural Fluid Registry

Breast CancerLung CancerLung Infection+2 more
UNC Lineberger Comprehensive Cancer Center9,999 enrolled1 locationNCT05620329
Recruiting
Not Applicable

Intraoperative Paravertebral Block and Postoperative Complications

Lung Cancer (Diagnosis)Video-assisted Thoracoscopic Surgery (VATS)Pulmonary Infections+8 more
Tongji Hospital500 enrolled1 locationNCT07211529
Recruiting

Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)

Pleural Effusion, MalignantAscites, MalignantCarcinoma+4 more
Travera Inc200 enrolled1 locationNCT05461430
Recruiting
Not Applicable

Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound

Malignant Pleural EffusionEffect of Patient Rotation on Pleurodesis Success and Patient ComfortPleurodesis
Ain Shams University30 enrolled1 locationNCT07147270
Recruiting
Not Applicable

Impact of Pleural Manometry on the Assessment and Treatment of Malignant Pleural Effusion: A Pilot Clinical Trial

Malignant Pleural Effusions (Mpe)
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau95 enrolled1 locationNCT07120867
Recruiting
Not Applicable

Pleural Irrigation With a Novel Devise.

Pleural Effusion Disorder
Beth Israel Deaconess Medical Center10 enrolled1 locationNCT06727578