Pleural Effusion Clinical Trials

45 recruitingLast updated: June 17, 2026

There are 45 actively recruiting pleural effusion clinical trials across 16 countries. Studies span Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4. Top locations include Pittsburgh, Pennsylvania, United States, Boston, Massachusetts, United States, Kuala Lumpur, Kuala Lumpur, Malaysia. Updated daily from ClinicalTrials.gov.


Pleural Effusion Trials at a Glance

45 actively recruiting trials for pleural effusion are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Not Applicable with 22 trials, with the heaviest enrollment activity in Pittsburgh, Boston, and Kuala Lumpur. Lead sponsors running pleural effusion studies include Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute), Beth Israel Deaconess Medical Center, and National University of Malaysia.

Browse pleural effusion trials by phase

Treatments under study

About Pleural Effusion Clinical Trials

Looking for clinical trials for Pleural Effusion? There are currently 20 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pleural Effusion trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pleural Effusion clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 45 trials

Recruiting

EX VIVO DRUG RESPONSE PROFILING AND OUTCOME PREDICTION IN LUNG ADENOCARCINOMA

Lung AdenocarcinomaMalignant Pleural Effusions (Mpe)
Sheba Medical Center400 enrolled1 locationNCT07636252
Recruiting

Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion

Pleural Effusion
Guy's and St Thomas' NHS Foundation Trust124 enrolled1 locationNCT05945043
Recruiting
Phase 4

Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema

EmpyemaPleural EffusionPleural Effusion Associated With Pulmonary Infection+5 more
University of North Carolina, Chapel Hill270 enrolled6 locationsNCT07095361
Recruiting
Phase 1Phase 2

First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion

Non-small Cell Lung CancerMalignant Pleural Effusions (Mpe)
Gang Hou105 enrolled1 locationNCT07332858
Recruiting
Phase 1Phase 2

A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC

NSCLC Stage IVMalignant Pleural Effusions
Wuhan YZY Biopharma Co., Ltd.96 enrolled1 locationNCT05543330
Recruiting

The PLEUral Effusion Rapid Analysis using DIPsticks (PLEURADIP) Study: Evaluation of Automatic Urine Dipstick Analysis as a Point of Care Test

Pleural Effusion
Western Sydney Local Health District200 enrolled1 locationACTRN12626000566336
Recruiting
Not Applicable

16F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or Segmentectomy

PneumothoraxPleural Effusion
University Hospital, Basel, Switzerland124 enrolled1 locationNCT06958848
Recruiting

Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases

PneumothoraxCOPDPneumonia+4 more
Assiut University700 enrolled1 locationNCT06983366
Recruiting
Not Applicable

DRAIN: DRainage in Acute Decompensated Heart faIlure With Pleural effusioNs

Congestive Heart Failure(CHF)Pleural Effusion Due to Congestive Heart Failure
Albany Medical College216 enrolled1 locationNCT07419360
Recruiting
Not Applicable

Confocal Laser Endomicroscopy Guided Medical Thoracoscopy for the Diagnosis of Pleural Disease

Pleural DiseasesPleural Effusion
China-Japan Friendship Hospital158 enrolled1 locationNCT06741839
Recruiting
Phase 1

Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors

Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)10 enrolled1 locationNCT07443020
Recruiting

Pleural Effusion Biomarkers in Lung Adenocarcinoma Patients

Lung AdenocarcinomaPleural EffusionBiomarkers
Fu Jen Catholic University100 enrolled1 locationNCT07012759
Recruiting
Not Applicable

Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

Postoperative Respiratory FailureMechanical PowerPostoperative Pulmonary Atelectasis+7 more
University General Hospital of Patras200 enrolled1 locationNCT07186933
Recruiting
Not Applicable

Pleuroscopy First Versus Thoracentesis First in Patients With Suspected Malignant Pleural Effusions

CancerPleural Effusion
Icahn School of Medicine at Mount Sinai98 enrolled2 locationsNCT06892691
Recruiting
Not Applicable

Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna Trial

PneumothoraxPleural EffusionLung Injury+3 more
Hospital Israelita Albert Einstein1,470 enrolled1 locationNCT06686251
Recruiting
Phase 1

Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease

Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
David Bartlett, MD10 enrolled1 locationNCT07192900
Recruiting
Not Applicable

Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System

Pleural Effusion
Johns Hopkins University200 enrolled6 locationsNCT03831386
Recruiting
Not Applicable

Effect of Bubble Positive Expiratory Pressure and Segmental Breathing Versus Incentive Spirometry in Pleural Effusion

Pleural Effusion
Riphah International University40 enrolled1 locationNCT07248774
Recruiting
Not Applicable

Normal Saline Flushing With And Without Heparin Lock In Maintaining Small Bore Intercostal Chest Catheter (ICC) Patency

Pleural Effusion
National University of Malaysia40 enrolled1 locationNCT06314620
Recruiting
Not Applicable

Virtual Reality: Distraction During Small Bore Intercostal Chest Drain Insertion

Pleural Effusion
National University of Malaysia80 enrolled1 locationNCT06247800