Phase 3 Preterm Clinical Trials
26 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 26 trials
Recruiting
Phase 2Phase 3
Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial
developmental delayGingivitisPeriodontitis+2 more
University of Washington6,000 enrolled1 locationNCT07424846
Recruiting
Phase 3
A Clinical Trial on Safety in Pregnant Women and How Well the Infant is Protected Against RSV-associated Lower Respiratory Tract Infection When the Pregnant Woman Receives the Approved RSV Vaccine Compared to a Placebo.
preterm labourRSV ImmunisationRSV Infections
University of Witwatersrand, South Africa13,000 enrolled11 locationsNCT06955728
Recruiting
Phase 3
Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial
Preterm deliveryObstetrical Complications
The George Washington University Biostatistics Center1,800 enrolled14 locationsNCT06980025
Recruiting
Phase 3
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
Preterm neonateSedation for Invasive Mechanical VentilationVery Preterm Neonates With Sedation for Invasive Mechanical Ventilation
Assistance Publique - Hôpitaux de Paris380 enrolled1 locationNCT06878703
Recruiting
Phase 3
Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries
Preterm BirthStillbirthSmall for Gestational Age (SGA)+1 more
NICHD Global Network for Women's and Children's Health1,134 enrolled7 locationsNCT06723392
Recruiting
Phase 3
Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation
Preterm Premature Rupture of Membrane
Assistance Publique - Hôpitaux de Paris850 enrolled1 locationNCT03976063
Recruiting
Phase 3
TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden
Preterm premature rupture of membranes (PPROM)
The Central and Eastern European Gynecologic Oncology Group138 enrolled2 locationsNCT07107477
Recruiting
Phase 3
Antenatal Melatonin Supplementation for Neuroprotection in Fetal Growth Restriction
Pregnancy PretermFetal Growth RetardationStillbirth and Fetal Death
Monash University336 enrolled12 locationsNCT05651347
Not Yet Recruiting
Phase 2Phase 3
Autologous cord blood-derived cell therapy for extremely preterm infants: An international, multicentre randomised controlled trial
preterm brain injury
Monash Health334 enrolled3 locationsACTRN12624000968572
Active
Phase 3Phase 4
Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants at Birth (The POLAR Trial).
Preterm Birth
Murdoch Children's Research Institute906 enrolled11 locationsACTRN12618001686291
Active
Phase 3
Preventing Lung Disease Using Surfactant + Steroid (The PLUSS Trial)
Extremely preterm birthRespiratory distress syndrome
The Melbourne Children's Trial Centre1,060 enrolled18 locationsACTRN12617000322336
Recruiting
Phase 3
Intravenous pentoxifylline as adjunct therapy to improve long-term disability in preterm infants
Late-onset sepsis (LOS)Preterm infantsNecrotising enterocolitis (NEC)+1 more
University of Sydney1,800 enrolled25 locationsACTRN12616000405415
Completed
Phase 3Phase 4
Effect of single versus multi-strain probiotic supplementation on the time to full enteral feeds in preterm neonates – a double blind randomised controlled trial
faecal short chain fatty acidsgut colonisationenteral nutrition in preterm neonates
Gayatri Jape172 enrolled1 locationACTRN12615000940572
Recruiting
Phase 3
Hypotension in Threatened Preterm Labour Treating with Initial Loading Dose of 30 mg versus 40 mg Nifedipine
hypotension in threatened preterm pregnant who treated with nifedipine
Khon Kaen Hospital90 enrolled1 locationACTRN12612000517875
Completed
Phase 3
MAGENTA - Magnesium Sulphate at 30 to 34 weeks' gestational age: Neuroprotection Trial
Complications of preterm infantCerebral PalsyNeuroprotection
University of Adelaide1,676 enrolled1 locationACTRN12611000491965
Completed
Phase 2Phase 3
The safety and efficacy of a locally available probiotic in premature infants.
all cause mortality and time to full feeds in preterm very low birthweight neonatesNecrotising Enterocolitis
Womens and Childrens Health Service120 enrolled1 locationACTRN12609000374268
Completed
Phase 3
Australasian Antenatal Study To Evaluate the Role Of Intramuscular Dexamethasone versus Betamethasone prior to preterm birth to increase survival free of childhood neurosensory disability – a randomised controlled trial
Long-term childhood neurosensory disability following antenatal corticosteroids given to women at risk of preterm birth at less than 34 weeks gestatation
Women’s and Children’s Hospital, SA1,499 enrolled1 locationACTRN12608000631303
Completed
Phase 3
Randomised trial of dopamine vs dobutamine for treatment of low systemic blood flow in very preterm infants
Low systemic blood flow in preterm infants
A/Prof Nick Evans45 enrolled1 locationACTRN12607000152426
Terminated
Phase 3
BOOST II: Benefits Of Oxygen Saturation Targeting Study
Preterm infants
NHMRC Clinical Trials Centre1,200 enrolled1 locationACTRN12605000055606
Completed
Phase 3
Optimising very preterm infant outcomes: an evidence based screening and surveillance method
Disability of very preterm infant
The University of Queensland202 enrolled1 locationACTRN12606000472572