Phase 2 Protein Clinical Trials
24 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 24 trials
Recruiting
Phase 2
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
Proteinuric Kidney Diseases
Boehringer Ingelheim132 enrolled147 locationsNCT07355296
Recruiting
Phase 2
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy
Autoimmune DiseaseProteinuriaGlomerular Disease+2 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)30 enrolled2 locationsNCT00977977
Recruiting
Phase 2
A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease
Proteinuric Kidney Disease
Maze Therapeutics56 enrolled81 locationsNCT06830629
Recruiting
Phase 2Phase 3
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
Proteinuric Kidney Disease
Vertex Pharmaceuticals Incorporated466 enrolled318 locationsNCT05312879
Recruiting
Phase 2
A Study to Investigate the Effects of Zibotentan/Dapagliflozin Combination Compared to Dapagliflozin Alone in Adult Participants With Chronic Kidney Disease and High Proteinuria
Chronic Kidney Disease With High Proteinuria
AstraZeneca224 enrolled15 locationsNCT06942910
Recruiting
Phase 2
A Study of DII235 in Adults With Elevated Lipoprotein(a)
Lipoprotein Disorder
Novartis Pharmaceuticals200 enrolled66 locationsNCT07235046
Recruiting
Phase 2
Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease With or Without Comorbidities
Proteinuric Kidney Disease
Vertex Pharmaceuticals Incorporated45 enrolled35 locationsNCT06794996
Recruiting
Phase 1Phase 2
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome
Ionis Pharmaceuticals, Inc.48 enrolled11 locationsNCT06430385
Recruiting
Phase 2
Phase 2 Study of Kylo-11 in ASCVD Patients With Elevated Lp(a)
Lipoprotein Disorder
Kylonova (Xiamen) Biopharma co., LTD.204 enrolled43 locationsNCT07327840
Recruiting
Phase 2
A Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of Treatment With AP1189 in Patients With iMN and Severe Proteinuria
Nephrotic Syndrome Due to Idiopathic Membranous NephropathySevere Proteinuria Due to Idiopathic Membranous Nephropathy
SynAct Pharma Aps23 enrolled1 locationNCT04456816
Recruiting
Phase 2
Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic Leukemia
Acute Lymphoblastic LeukemiaRefractory Acute Lymphoblastic LeukemiaBlast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive+5 more
M.D. Anderson Cancer Center90 enrolled1 locationNCT03263572
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)
Muscular DystrophyLimb Girdle Muscular DystrophyLGMD2I+6 more
AskBio Inc10 enrolled6 locationsNCT05230459
Recruiting
Phase 2
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
Cognitive DysfunctionAlzheimer DiseaseFatty Acids, Omega-3+3 more
Michal Schnaider Beeri, Ph.D.20 enrolled1 locationNCT07392723
Recruiting
Phase 1Phase 2
A Study of SRSD216 in Patients With Elevated Lipoprotein (a)
Hyperlipoproteinemia (a)
Sirius Therapeutics Co., Ltd.84 enrolled1 locationNCT07172646
Recruiting
Phase 2
Ruxolitinib in Treating Patients With Hypereosinophilic Syndrome or Primary Eosinophilic Disorders
Blasts More Than 5 Percent of Bone Marrow Nucleated CellsBCR-JAK2 Fusion Protein ExpressionBlasts 20 Percent or Less of Peripheral Blood White Cells+2 more
William Shomali10 enrolled4 locationsNCT03801434
Recruiting
Phase 1Phase 2
Safety and Efficacy of PMT Therapy of hPAP
Hereditary Pulmonary Alveolar Proteinosis
Children's Hospital Medical Center, Cincinnati3 enrolled1 locationNCT05761899
Recruiting
Phase 1Phase 2
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Breast CancerEsophageal CancerGastric Cancer+13 more
Tanabe Pharma America, Inc.27 enrolled6 locationsNCT06943521
Recruiting
Phase 1Phase 2
Peptide Vaccine To Prevent Acquired Resistance In Patients With Advanced ALK+ NSCLC
NSCLC Stage IVALK Fusion Protein Expression
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins12 enrolled1 locationNCT05950139
Recruiting
Phase 2
The Diagnostic Accuracy and Clinical Value of FAPI PET in Pleural Mesothelioma
CancerPleural MesotheliomaPleural Diseases+2 more
Aalborg University Hospital70 enrolled1 locationNCT06790082
Recruiting
Phase 2
Beneficial Effect of Amiloride on Progression of Chronic Kidney Disease
Chronic Kidney Disease(CKD)Proteinuria
Odense University Hospital40 enrolled1 locationNCT06923709