Phase 3 Rectal Cancer Clinical Trials
15 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–15 of 15 trials
Recruiting
Phase 3
Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer
Rectal Cancer
Yanhong Deng582 enrolled1 locationNCT04215731
Recruiting
Phase 3
Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer
Rectal Cancer
Ralf Hofheinz550 enrolled1 locationNCT04495088
Recruiting
Phase 3
Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer
Advanced CancerRectal Cancer
Assistance Publique - Hôpitaux de Paris540 enrolled1 locationNCT03875781
Recruiting
Phase 3
Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
Rectal Cancer
Canadian Cancer Trials Group250 enrolled100 locationsNCT06205485
Recruiting
Phase 2Phase 3
Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer (MODIFI-RC-II)
Rectal CancerRadiotherapyNeoadjuvant Therapies+1 more
Sixth Affiliated Hospital, Sun Yat-sen University430 enrolled1 locationNCT06958432
Recruiting
Phase 3
Planed Organ Preservation for Low Rectal Cancer After Neoadjuvant Chemotherapy (OPLAR)
Rectal Cancer
West China Hospital186 enrolled1 locationNCT07070622
Recruiting
Phase 3
Node-sparing Short-Course Radiation Combined With CAPOX and Tislelizumab for MSS Rectal Cancer
Rectal Cancer
Sir Run Run Shaw Hospital170 enrolled1 locationNCT06507371
Recruiting
Phase 2Phase 3
Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.
Radiotherapy Side EffectNeoadjuvant TherapyChemotherapy+8 more
National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos400 enrolled1 locationNCT06758830
Recruiting
Phase 3
Prophylactic Mesh Placement During Stoma Closure After Low Anterior Resection
SurgeryRectal CancerNeoplasms Malignant+1 more
Blokhin's Russian Cancer Research Center142 enrolled1 locationNCT05939687
Recruiting
Phase 3
Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi)
Rectal Cancer
Peking University Cancer Hospital & Institute472 enrolled1 locationNCT06229041
Recruiting
Phase 3
The Efficacy of Primary Total Mesorectal Excision (TME) Surgery Versus Neoadjuvant Chemotherapy Combined With TME Surgery in Low-risk Locally Advanced Rectal Cancer
Rectal Cancer
Sun Yat-sen University766 enrolled6 locationsNCT05984485
Recruiting
Phase 3
Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma
Rectal Cancer
Sir Run Run Shaw Hospital108 enrolled1 locationNCT05752136
Recruiting
Phase 3
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome
Rectal CancerLow Anterior Resection Syndrome
University of Aarhus114 enrolled1 locationNCT04087421
Recruiting
Phase 3
Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer
Rectal Cancer
Fudan University300 enrolled1 locationNCT05201430
Recruiting
Phase 3
Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation
Rectal Cancer
Sun Yat-sen University776 enrolled2 locationsNCT03671252