Reduced Ejection Fraction Clinical Trials

1 recruiting

Reduced Ejection Fraction Trials at a Glance

76 actively recruiting trials for reduced ejection fraction are listed on ClinicalTrialsFinder across 6 cities in 45 countries. The largest study group is Not Applicable with 33 trials, with the heaviest enrollment activity in New York, Houston, and Baltimore. Lead sponsors running reduced ejection fraction studies include Imperial College London, Salubris Biotherapeutics Inc, and The University of Texas Health Science Center at San Antonio.

Browse reduced ejection fraction trials by phase

Treatments under study

About Reduced Ejection Fraction Clinical Trials

Looking for clinical trials for Reduced Ejection Fraction? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Reduced Ejection Fraction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Reduced Ejection Fraction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 76 trials

Recruiting
Not Applicable

Developing a Digital Aid to Improve ICD Decisions

Heart Failure and Reduced Ejection Fraction
Stanford University600 enrolled2 locationsNCT07084142
Recruiting
Phase 3

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

ObesityHeart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection Fraction
Amgen5,056 enrolled596 locationsNCT07037459
Recruiting
Not Applicable

Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)

Heart Failure With Reduced Ejection Fraction
Beijing Anzhen Hospital252 enrolled6 locationsNCT07352891
Recruiting

An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting

Chronic Heart Failure With Reduced Ejection Fraction
Bayer1,350 enrolled1 locationNCT06148935
Recruiting
Phase 3

Selenium Intervention Registry Randomized Trial in Heart Failure

Heart FailureHeart Failure and Reduced Ejection FractionHeart Failure and Preserved Ejection Fraction+3 more
Skane University Hospital4,326 enrolled11 locationsNCT07543562
Recruiting
Phase 4

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score

Heart Failure With Reduced Ejection Fraction
University of Michigan100 enrolled1 locationNCT07490067
Recruiting
Phase 1

A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

Heart Failure With Reduced Ejection Fraction
Novartis Pharmaceuticals12 enrolled3 locationsNCT07465653
Recruiting
Not Applicable

Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure

Heart Failure With Reduced Ejection Fraction (HFrEF)
Azienda Unita Sanitaria Locale di Piacenza90 enrolled1 locationNCT07518030
Recruiting
Not Applicable

Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure

Heart Failure With Reduced Ejection Fraction
VisCardia Inc.270 enrolled1 locationNCT06552637
Recruiting
Not Applicable

Heart Failure Management for Patient With CIED Remotely Monitored

Heart FailureHeart Failure With Reduced Ejection Fraction (HFrEF)Heart Failure NYHA Class III+1 more
Implicity1,132 enrolled1 locationNCT07247032
Recruiting

PBMC as Biomarkers of Diabetic Cardiomyopathy

Metabolic SyndromeType 2 DiabetesHeart Failure With Preserved Ejection Fraction+1 more
Hospices Civils de Lyon175 enrolled1 locationNCT05651919
Recruiting

Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure

Heart Failure and Reduced Ejection FractionNYHA Class III Heart Failure
Impulse Dynamics4,200 enrolled1 locationNCT07209098
Recruiting
Not Applicable

Effectiveness of Video Monitoring and Care Transition for Heart Failure Patients (EVIT-HF): Randomized Clinical Trial

Heart Failure With Reduced Ejection Fraction (HFrEF)
Federal University of Uberlandia368 enrolled1 locationNCT06731166
Recruiting

AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices

Cardiovascular DiseasesHeart Failure With Reduced Ejection Fraction (HFrEF)Chronic Heart Failure
University of Salerno205 enrolled1 locationNCT06909682
Recruiting

Prospective Evaluation of AI-ECG for SHD Detection

Heart Failure With Preserved Ejection Fraction (HFpEF; Diagnosis)Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)Pulmonary Hypertension (Diagnosis)+1 more
Imperial College London590 enrolled5 locationsNCT07057466
Recruiting

Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System

Heart FailureHeart Failure With Reduced Ejection FractionHeart Failure NYHA Class IV+1 more
Yale University40,000 enrolled1 locationNCT04237701
Recruiting
Not Applicable

Digital Support Program for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 Study

Heart Failure With Reduced Ejection Fraction
Linkoeping University240 enrolled1 locationNCT07275931
Recruiting
Phase 2

Swedish Cardiac And Renal Failure Study-1

Chronic Kidney DiseaseHFrEF - Heart Failure With Reduced Ejection Fraction
Karolinska Institutet40 enrolled1 locationNCT07029503
Recruiting
Phase 2Phase 3

Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy

Heart Failure With Reduced Ejection FractionHeart Rhythm Disorder
Herlev and Gentofte Hospital348 enrolled1 locationNCT06128980
Recruiting
Not Applicable

Comparing Three Types of Specialist Pacemakers to Improve Heart Function and Reduce Rhythm Problems in Heart Failure

Heart Failure and Reduced Ejection FractionDyssynchrony
Imperial College London60 enrolled1 locationNCT07430553