Reduced Ejection Fraction Clinical Trials

86 recruitingLast updated: June 18, 2026

There are 86 actively recruiting reduced ejection fraction clinical trials across 45 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include New York, New York, United States, Cincinnati, Ohio, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Reduced Ejection Fraction Trials at a Glance

86 actively recruiting trials for reduced ejection fraction are listed on ClinicalTrialsFinder across 6 cities in 45 countries. The largest study group is Not Applicable with 38 trials, with the heaviest enrollment activity in New York, Cincinnati, and Houston. Lead sponsors running reduced ejection fraction studies include Imperial College London, Impulse Dynamics, and Salubris Biotherapeutics Inc.

Browse reduced ejection fraction trials by phase

Treatments under study

About Reduced Ejection Fraction Clinical Trials

Looking for clinical trials for Reduced Ejection Fraction? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Reduced Ejection Fraction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Reduced Ejection Fraction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 86 trials

Recruiting

Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG

Heart Failure With Reduced Ejection FractionHypertension, Pulmonary
Eko Devices, Inc.3,850 enrolled4 locationsNCT07087613
Recruiting

An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting

Chronic Heart Failure With Reduced Ejection Fraction
Bayer1,350 enrolled1 locationNCT06148935
Recruiting
Not Applicable

Effectiveness of Video Monitoring and Care Transition for Heart Failure Patients (EVIT-HF): Randomized Clinical Trial

Heart Failure With Reduced Ejection Fraction (HFrEF)
Federal University of Uberlandia140 enrolled1 locationNCT06731166
Recruiting
Not Applicable

Eccentric Muscle Training in Cardiac Rehabilitation

Strength Training EffectsHFrEF - Heart Failure With Reduced Ejection Fraction
University Hospital, Antwerp3 enrolled1 locationNCT07636343
Recruiting

Feasibility and Effectiveness of a Ring-Type Blood Pressure Device (CART-BP) Compared With 24-Hour Ambulatory Blood Pressure Monitoring in HFrEF

Heart Failure With Reduced Ejection Fraction; Hypertension
Keimyung University Dongsan Medical Center100 enrolled1 locationNCT07626879
Recruiting

AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

Heart FailureCardiotoxicityMyocardial Infarction+12 more
Peerbridge Health, Inc2,000 enrolled8 locationsNCT06699056
Recruiting
Not Applicable

High Fat Diet for Cardiac Metabolic Reprogramming

Heart Failure With Reduced Ejection FractionNon-ischemic Dilated Cardiomyopathy
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III80 enrolled5 locationsNCT06747429
Recruiting
Phase 3

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

ObesityHeart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection Fraction
Amgen5,056 enrolled605 locationsNCT07037459
Recruiting
Not Applicable

Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure

Heart Failure With Reduced Ejection Fraction (HFrEF)
Azienda Unita Sanitaria Locale di Piacenza80 enrolled1 locationNCT07518030
Recruiting
Not Applicable

Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection Fraction

Heart Failure With Reduced Ejection Fraction
Medical University of Silesia100 enrolled1 locationNCT07595809
Recruiting
Not Applicable

Assessment of CCM in HF With Higher Ejection Fraction

Heart FailureHeart Failure With Preserved Ejection FractionDiastolic Heart Failure+2 more
Impulse Dynamics1,500 enrolled105 locationsNCT05064709
Recruiting
Phase 3

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

Heart FailureHeart Failure With Reduced Ejection Fraction
Cytokinetics1,800 enrolled185 locationsNCT06736574
Recruiting
Not Applicable

Developing a Digital Aid to Improve ICD Decisions

Heart Failure and Reduced Ejection Fraction
Stanford University600 enrolled2 locationsNCT07084142
Recruiting
Not Applicable

Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)

Heart Failure With Reduced Ejection Fraction
Beijing Anzhen Hospital252 enrolled6 locationsNCT07352891
Recruiting
Phase 3

Selenium Intervention Registry Randomized Trial in Heart Failure

Cognitive functioningHeart FailureHeart Failure and Reduced Ejection Fraction+4 more
Skane University Hospital4,326 enrolled11 locationsNCT07543562
Recruiting
Phase 1

A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

Heart Failure With Reduced Ejection Fraction
Novartis Pharmaceuticals12 enrolled3 locationsNCT07465653
Recruiting
Phase 4

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score

Heart Failure With Reduced Ejection Fraction
University of Michigan100 enrolled1 locationNCT07490067
Recruiting
Not Applicable

Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure

Heart Failure With Reduced Ejection Fraction
VisCardia Inc.270 enrolled1 locationNCT06552637
Recruiting
Not Applicable

Heart Failure Management for Patient With CIED Remotely Monitored

Heart FailureHeart Failure With Reduced Ejection Fraction (HFrEF)Heart Failure NYHA Class III+3 more
Implicity1,132 enrolled1 locationNCT07247032
Recruiting

PBMC as Biomarkers of Diabetic Cardiomyopathy

Metabolic SyndromeType 2 DiabetesHeart Failure With Preserved Ejection Fraction+1 more
Hospices Civils de Lyon175 enrolled1 locationNCT05651919