Respiratory distress syndrome Clinical Trials

196 recruitingLast updated: July 25, 2026

There are 196 actively recruiting respiratory distress syndrome clinical trials across 54 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Houston, Texas, United States, New York, New York, United States, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Respiratory distress syndrome Trials at a Glance

196 actively recruiting trials for respiratory distress syndrome are listed on ClinicalTrialsFinder across 6 cities in 54 countries. The largest study group is Not Applicable with 76 trials, with the heaviest enrollment activity in Houston, New York, and Beijing. Lead sponsors running respiratory distress syndrome studies include Southeast University, China, Assistance Publique - Hôpitaux de Paris, and PPD Development, LP.

Browse respiratory distress syndrome trials by phase

Treatments under study

About Respiratory distress syndrome Clinical Trials

Looking for clinical trials for Respiratory distress syndrome? There are currently 27 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Respiratory distress syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Respiratory distress syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 196 trials

Recruiting
Phase 4

Identifying an Optimal Corticosteroid Dosage Regimen for Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome (ARDS)
National Taiwan University Hospital300 enrolled1 locationNCT07711964
Recruiting
Phase 3

Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment

Acute Respiratory Distress Syndrome (ARDS)
Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion156 enrolled1 locationNCT07317050
Recruiting
Not Applicable

Effect of EIT-guided PEEP in ARDS Patients

ARDS (Acute Respiratory Distress Syndrome)
Southeast University, China2,400 enrolled17 locationsNCT06990477
Recruiting

Validation and Precision Treatment of Inflammatory Subphenotypes in Acute Respiratory Distress Syndrome: A Multicenter Cohort Study

Acute Respiratory Distress Syndrome
Southeast University, China500 enrolled1 locationNCT07289711
Recruiting

BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and Radiomics

ARDS (Acute Respiratory Distress Syndrome)
Medical University of Vienna130 enrolled1 locationNCT07633366
Recruiting
Not Applicable

Lung EIT Image Guide Ventilation in ARDS

ARDS (Acute Respiratory Distress Syndrome)
Peking Union Medical College Hospital574 enrolled1 locationNCT07309783
Recruiting
Not Applicable

Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients.

ARDS (Acute Respiratory Distress Syndrome)
Hospital Dr. Franco Ravera Zunino52 enrolled1 locationNCT07603310
Recruiting
Not Applicable

Evaluation of Serial Lung Ultrasound Data After Surfactant Treatments Applied With Different Methods in Preterm Babies

Respiratory Distress Syndrome, NewbornNewborn Complication
Konya City Hospital68 enrolled1 locationNCT06880016
Recruiting
Not Applicable

Height Measurement Procedures Influence the Risk of Ventilator-induced Lung Injury in ARDS

ventilator-induced lung injuryTidal VolumeAcute Respiratory Distress Syndrome+2 more
Centre Hospitalier Universitaire, Amiens39 enrolled1 locationNCT07595926
Recruiting

Advanced Respiratory Monitoring for Safer Mechanical Ventilation in Patients Without Respiratory Failure

Developing Acute Respiratory Distress Syndrome
Istituto Clinico Humanitas40 enrolled1 locationNCT07686315
Recruiting
Not Applicable

Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure

Intensive Care Units, NeonatalRespiratory Distress Syndrome, NewbornPulmonary Surfactants
Connecticut Children's Medical Center52 enrolled1 locationNCT06446453
Recruiting
Not Applicable

Assessment of Airway Opening Pressure in Invasively Ventilated Children

Acute Respiratory Distress Syndrome in Children
Assistance Publique - Hôpitaux de Paris50 enrolled1 locationNCT07262541
Recruiting
Not Applicable

Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)

Respiratory FailureCritical IllnessARDS (Acute Respiratory Distress Syndrome)+1 more
Peking Union Medical College Hospital208 enrolled1 locationNCT07307066
Recruiting
Phase 3

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

Respiratory FailureAcute Respiratory Distress Syndrome
Beth Israel Deaconess Medical Center1,100 enrolled33 locationsNCT06066502
Recruiting
Not Applicable

How Different Levels of CPAP Affect Oxygen Delivery and Lung Expansion in Preterm Infants

Respiratory Distress Syndrome (Neonatal)Respiratory Distress of Newborn
University of Arkansas10 enrolled2 locationsNCT07674953
Recruiting
Phase 2

A Study of GEn-1124 in Subjects With Acute Respiratory Distress Syndrome (ARDS)

Respiratory Distress Syndrome, Acute
GEn1E Lifesciences52 enrolled11 locationsNCT05795465
Recruiting
Phase 2

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

InfectionsAcute Respiratory Distress Syndrome
BioAegis Therapeutics Inc.600 enrolled70 locationsNCT05947955
Recruiting
Not Applicable

Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration

Respiratory Distress Syndrome (Neonatal)Surfactant Deficiency Syndrome Neonatal
University of Texas Southwestern Medical Center100 enrolled1 locationNCT07426016
Recruiting
Early Phase 1

A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome

ARDS (Moderate or Severe)ARDS (Acute Respiratory Distress Syndrome)
Shanghai Zhongshan Hospital24 enrolled1 locationNCT07558538
Recruiting

Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.

ARDS (Acute Respiratory Distress Syndrome)
University of Pennsylvania36 enrolled1 locationNCT07125079