Respiratory distress syndrome Clinical Trials

180 recruitingLast updated: May 21, 2026

There are 180 actively recruiting respiratory distress syndrome clinical trials across 52 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1. Top locations include Houston, Texas, United States, New York, New York, United States, Cleveland, Ohio, United States. Updated daily from ClinicalTrials.gov.


Respiratory distress syndrome Trials at a Glance

180 actively recruiting trials for respiratory distress syndrome are listed on ClinicalTrialsFinder across 6 cities in 52 countries. The largest study group is Not Applicable with 69 trials, with the heaviest enrollment activity in Houston, New York, and Cleveland. Lead sponsors running respiratory distress syndrome studies include Southeast University, China, Assistance Publique - Hôpitaux de Paris, and PPD Development, LP.

Browse respiratory distress syndrome trials by phase

About Respiratory distress syndrome Clinical Trials

Looking for clinical trials for Respiratory distress syndrome? There are currently 26 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Respiratory distress syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Respiratory distress syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 180 trials

Recruiting

Study of the Immunological Pathophysiological Mechanisms Associated With Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome (ARDS)
Assistance Publique - Hôpitaux de Paris50 enrolled1 locationNCT07395076
Recruiting
Phase 4

Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes

Cerebral oxygen saturationInfant Respiratory Distress SyndromeCerebral Oxygenation+3 more
Medical University of Graz76 enrolled1 locationNCT07261787
Recruiting
Phase 3

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

Respiratory FailureAcute Respiratory Distress Syndrome
Beth Israel Deaconess Medical Center1,100 enrolled33 locationsNCT06066502
Recruiting
Phase 3

RECOMMEND Platform Trial

Intensive Care MedicineCritical IllnessCardiac Arrest (CA)+2 more
Australian and New Zealand Intensive Care Research Centre600 enrolled3 locationsNCT06526533
Recruiting
Phase 2

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

Acute Respiratory Distress Syndrome (ARDS)ARDSAcute Respiratory Distress Syndrome+1 more
PPD Development, LP200 enrolled40 locationsNCT06701669
Recruiting
Phase 2

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

Acute Respiratory Distress Syndrome (ARDS)ARDSAcute Respiratory Distress Syndrome+1 more
PPD Development, LP200 enrolled40 locationsNCT06701682
Recruiting
Phase 2

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

Acute Respiratory Distress Syndrome (ARDS)ARDSAcute Respiratory Distress Syndrome+1 more
PPD Development, LP200 enrolled40 locationsNCT06701656
Recruiting
Phase 2

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

Acute Respiratory Distress Syndrome (ARDS)ARDSAcute Respiratory Distress Syndrome+1 more
PPD Development, LP600 enrolled40 locationsNCT06703073
Recruiting
Not Applicable

Effect of Postural Drainage With or Without Thoracic Squeezing on O2 and Respiratory Rate in Infant With RDS.

Respiratory distress syndrome
Riphah International University14 enrolled1 locationNCT07579013
Recruiting
Phase 3

Pirfenidone to Prevent Fibrosis in Ards.

Acute Respiratory Distress Syndrome (ARDS)
Università Vita-Salute San Raffaele130 enrolled17 locationsNCT05075161
Recruiting

Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol

Intensive Care MedicineOpioid analgesiaExtracorporeal Membrane Oxygenation (ECMO)+5 more
Guy's and St Thomas' NHS Foundation Trust120 enrolled1 locationNCT07032987
Recruiting
Not Applicable

Optimising Breathing Support at Extubation in Very Preterm Infants: A Clinical Study

Respiratory Distress Syndrome in Premature InfantRespiratory Distress Syndrome, Newborn
Murdoch Childrens Research Institute134 enrolled2 locationsNCT07251790
Recruiting
Not Applicable

A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants

Infant Respiratory Distress SyndromeIntubationInfant, Newborn+2 more
University College Dublin840 enrolled17 locationsNCT06757543
Recruiting
Phase 4

Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome

SurfactantRespiratory Distress Syndrome in Premature InfantsRespiratory Distress Syndrome (RDS)
Uludag University234 enrolled5 locationsNCT07350018
Recruiting

The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study

Acute Respiratory Distress Syndrome (ARDS)Acute Respiratory FailurePneumonia+2 more
First Affiliated Hospital of Wannan Medical College41 enrolled1 locationNCT07542366
Recruiting

Breathing Patterns in Infants Before and After Extubation

Preterm neonateRespiratory Distress Syndrome (RDS)
Christiana Care Health Services30 enrolled1 locationNCT07542301
Recruiting
Phase 3

Safety and Efficacy of APC-0101 in Preterm Infants With Respiratory Distress Syndrome

Respiratory distress syndromePre-term Infants
Aerogen Pharma Limited520 enrolled12 locationsNCT06776783
Recruiting
Phase 2

MINImising Total Radiation EXposure in Preterm Infants

neonatal respiratory distress syndromePreterm neonate
Western Health, Australia180 enrolled1 locationNCT06975189
Recruiting

Prediction of Inspiratory Effort Response to High PEEP in Patients Recovering From ARDS

Acute Respiratory Distress Syndrome
Sanatorio Anchorena San Martin30 enrolled1 locationNCT04524091
Recruiting
Phase 1Phase 2

Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia

Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmCOVID-19 Infection+2 more
M.D. Anderson Cancer Center70 enrolled1 locationNCT04565665