Mechanical Ventilation Clinical Trials

165 recruitingLast updated: July 10, 2026

There are 165 actively recruiting mechanical ventilation clinical trials across 40 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1. Top locations include Paris, France, Beijing, Beijing Municipality, China, Nanjing, Jiangsu, China. Updated daily from ClinicalTrials.gov.


Mechanical Ventilation Trials at a Glance

165 actively recruiting trials for mechanical ventilation are listed on ClinicalTrialsFinder across 6 cities in 40 countries. The largest study group is Not Applicable with 83 trials, with the heaviest enrollment activity in Paris, Beijing, and Nanjing. Lead sponsors running mechanical ventilation studies include Assistance Publique - Hôpitaux de Paris, University Health Network, Toronto, and Ankara Etlik City Hospital.

Browse mechanical ventilation trials by phase

Treatments under study

About Mechanical Ventilation Clinical Trials

Looking for clinical trials for Mechanical Ventilation? There are currently 83 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mechanical Ventilation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mechanical Ventilation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 165 trials

Recruiting
Not Applicable

COMPARE-VENT Feasibility Pilot Study

Cardiogenic ShockMechanical VentilationCritical Illness+4 more
Mayo Clinic75 enrolled1 locationNCT07656259
Recruiting
Phase 2Phase 3

Effect of Interferon Gamma as a Treatment for Post-aggressive Immunosuppression in Intensive Care Units, a Randomized Bayesian Double-blind Controlled Trial Versus Placebo

Post-aggressive ImmunosuppressionAdult Patients Admitted to Intensive Care With Initial Severity (SOFA of the First 24 Hours Post-admission ≥ 6Adult Under Mechanical Ventilation, and Presenting an mHLA-DR Less Than 8,000AB/C
Assistance Publique - Hôpitaux de Paris170 enrolled2 locationsNCT06694740
Recruiting

Intelligent Lung Support in the Intensive Care Unit

Intensive Care MedicineMechanical Ventilation
Technische Universität Dresden530 enrolled5 locationsNCT06595602
Recruiting
Not Applicable

Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation

Prolonged Mechanical VentilationExercise TrainingExoskeleton Device+2 more
Fu Jen Catholic University30 enrolled1 locationNCT07445035
Recruiting

Prediction of the Spontaneous Breathing Test Success Using Biosignal and Biomarker in Critical Care Unit by a Machine Learning Approach

Weaning From Mechanical Ventilation in Care Unit
Centre Hospitalier Universitaire de Nice500 enrolled1 locationNCT05886803
Recruiting

ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia

Mechanical Ventilation ComplicationVentilator-acquired Pneumonia
Region Skane400 enrolled4 locationsNCT07245888
Recruiting
Phase 2

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

Chronic respiratory failureNon-invasive ventilationRespiratory Insufficiency+7 more
University of Pennsylvania48 enrolled3 locationsNCT07071935
Recruiting
Not Applicable

Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients

Mechanical VentilationIntensive Care (ICU)
Reinier de Graaf Groep56 enrolled5 locationsNCT07077174
Recruiting
Not Applicable

Effect of Post-suction Recruitment on Lung Volume in Mechanically Ventilated ICU Patients

Mechanical Ventilation
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer32 enrolled1 locationNCT07358039
Recruiting
Phase 4

Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation

SurgeryMechanical Ventilation ComplicationCritical Illness+3 more
Beijing Shijitan Hospital, Capital Medical University306 enrolled1 locationNCT06575530
Recruiting

Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Robot-Assisted Radical Prostatectomy

Prostatic NeoplamsMechanical VentilationPostoperative Pulmonary Complications (PPCs)+2 more
Ankara Etlik City Hospital76 enrolled1 locationNCT07610824
Recruiting

Flow-Controlled vs Volume-Controlled Ventilation in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery

Mechanical VentilationObesity, MorbidBariatric Surgery (Sleeve Gastrectomy )
Ankara Training and Research Hospital34 enrolled1 locationNCT07641829
Recruiting
Phase 2Phase 3

Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome

Mechanical Ventilation ComplicationAcute Respiratory Distress SyndromeSedation Complication
Guy's and St Thomas' NHS Foundation Trust20 enrolled1 locationNCT06014138
Recruiting
Not Applicable

Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation

Mechanical Ventilation ComplicationAcute Hypoxemic Respiratory Failure
Centre for Medical Sciences36 enrolled1 locationNCT06921655
Recruiting
Not Applicable

High Flow Tracheal Oxygen for Weaning of Tracheostomized Patients

High Flow Oxygen TherapyTracheostomized PatientsMechanical Ventilation Weaning
King Faisal Specialist Hospital & Research Center88 enrolled1 locationNCT07559591
Recruiting
Not Applicable

Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery

Mechanical VentilationLumbar Disc Herniation Surgery
Ankara Etlik City Hospital80 enrolled1 locationNCT07614555
Recruiting
Not Applicable

Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome

ARDS, HumanMechanical VentilationLung Ultrasound
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)538 enrolled10 locationsNCT05492344
Recruiting
Not Applicable

Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)

Mechanical Ventilation ComplicationPulmonary Edema
Centre Hospitalier Universitaire de Nice250 enrolled3 locationsNCT05226247
Recruiting
Not Applicable

Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials

Weaning Invasive Mechanical VentilationWeaning-induced Pulmonary EdemaWeaning Failure of Mechanical Ventilation+2 more
Centre Hospitalier Régional d'Orléans24 enrolled1 locationNCT06923267
Recruiting
Not Applicable

Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure

Neonatal Brain Injuryperinatal morbidityMechanical Ventilation+10 more
Medical College of Wisconsin320 enrolled1 locationNCT07274527