Early Phase 1 SMA Clinical Trials
26 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 26 trials
Recruiting
Early Phase 1
Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Lymphoma (SLL)
National Heart, Lung, and Blood Institute (NHLBI)30 enrolled1 locationNCT07428707
Recruiting
Early Phase 1
Safety and Preliminary Efficacy of [177Lu]Lu-RTX-2358 Combined With Immune Checkpoint Inhibitors in Patients With FAP-positive Metastatic Non-Small Cell Lung Cancer
Metastatic Non Small Cell Lung Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology36 enrolled1 locationNCT07689643
Recruiting
Early Phase 1
CAR BCMA-70 CAR-T Cells for the Treatment of High-risk Plasma Cell Neoplasms
High-risk Plasma Cell Neoplasms
Affiliated Hospital to Academy of Military Medical Sciences20 enrolled1 locationNCT07416682
Recruiting
Early Phase 1
64Cu-LLP2A for Imaging Hematologic Malignancies
Chronic Lymphocytic LeukemiaMultiple MyelomaFollicular Lymphoma+4 more
Washington University School of Medicine42 enrolled1 locationNCT06636175
Recruiting
Early Phase 1
CAR 70-BCMA CAR-T Cells for the Treatment of Relapsed or Refractory Plasma Cell Neoplasms
Relapsed or Refractory Plasma Cell Neoplasms
The General Hospital of Western Theater Command20 enrolled1 locationNCT07519187
Recruiting
Early Phase 1
Human Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular Vesicles for the Treatment of Dry Eye Disease
Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular VesiclesDry-Eye Disease
The First Affiliated Hospital of Xiamen University20 enrolled1 locationNCT07623382
Recruiting
Early Phase 1
A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma
Plasmablastic LymphomaAnn Arbor Stage I Diffuse Large B-Cell LymphomaAnn Arbor Stage II Diffuse Large B-Cell Lymphoma+2 more
AIDS Malignancy Consortium15 enrolled8 locationsNCT04139304
Recruiting
Early Phase 1
Loratadine for the Reduction of G-CSF Induced Bone Pain in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization
Plasma Cell Myeloma
Rutgers, The State University of New Jersey70 enrolled2 locationsNCT04211259
Recruiting
Early Phase 1
177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors
Endometrial CancerNon-small Cell Lung CancerTNBC - Triple-Negative Breast Cancer+6 more
Radiopharm Theranostics, Ltd30 enrolled5 locationsNCT06305962
Recruiting
Early Phase 1
Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer
Stage IV Lung Cancer AJCC v8Stage IVA Lung Cancer AJCC v8Stage IVB Lung Cancer AJCC v8+1 more
Emory University15 enrolled1 locationNCT05493566
Recruiting
Early Phase 1
Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer
Lung CancerNon-small Cell Lung CancerSmall Cell Lung Carcinoma
UNC Lineberger Comprehensive Cancer Center24 enrolled1 locationNCT05620342
Recruiting
Early Phase 1
[177Lu]Lu-AKIR001 First-in-human Study
Thyroid Gland Anaplastic CarcinomaPoorly Differentiated Thyroid CarcinomaCancer Head and Neck+3 more
Karolinska University Hospital15 enrolled1 locationNCT06639191
Recruiting
Early Phase 1
Universal CAR-T Cells (REVO-UWD-03) for Advanced Hepatocellular Carcinoma and Lung Cancer
NSCLC (Advanced Non-small Cell Lung Cancer)HCC - Hepatocellular Carcinoma
Wondercel Biotech (ShenZhen)60 enrolled2 locationsNCT06653023
Recruiting
Early Phase 1
CART123 T Cells in Relapsed or Refractory CD123+ Hematologic Malignancies: A Dose Escalation Phase I Trial
Myelodysplastic Syndromes (MDS)Precursor Cell Lymphoblastic Leukemia-LymphomaBlastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)+1 more
Institute of Hematology and Blood Transfusion, Czech Republic18 enrolled1 locationNCT06765876
Recruiting
Early Phase 1
TC-D101 Cell Therapy for Patients With DLL3-Positive SCLC
Small Cell Lung Cancer ( SCLC )CAR-T Cell Therapy
TCRCure Biopharma Ltd.24 enrolled1 locationNCT07246304
Recruiting
Early Phase 1
A Study of CT0596 in Relapsed/Refractory Multiple Myeloma and Relapsed/ Refractory Plasma Cell Leukemia
Relapsed/Refractory Multiple MyelomaRelapsed/Refractory Plasma Cell Leukemia
The First Affiliated Hospital of Soochow University24 enrolled1 locationNCT06730256
Recruiting
Early Phase 1
A Study of CT0596 in Plasma Cell Leukemia
Plasma Cell Leukemia
Institute of Hematology & Blood Diseases Hospital, China27 enrolled1 locationNCT06988059
Recruiting
Early Phase 1
Safety and Efficacy of Metabolically Armed BCMA CAR-T Cells (Meta10-BCMA) in the Treatment of r/r Plasma Cell Neoplasms Clinical Research
Multiple Myeloma (MM)Plasma Cell Leukemia (PCL)AL Amyloidosis (AL)
Anhui Provincial Hospital36 enrolled1 locationNCT07085559
Recruiting
Early Phase 1
A Molecular Probe Targeting BCMA for the Clinical Diagnosis of Multiple Myeloma
Multiple Myeloma and Malignant Plasma Cell Neoplasms
Peking University First Hospital50 enrolled2 locationsNCT06717113
Recruiting
Early Phase 1
68Ga-PSFA PET Imaging in Patients With PSMA/FAP Positive Disease
Positron Emission TomographyFAPPSMA
First Affiliated Hospital of Chongqing Medical University30 enrolled1 locationNCT06387381