Phase 1 Symptom Clinical Trials
26 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 26 trials
Recruiting
Phase 1
Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria
Spinal Cord InjuriesBacteriuriaAsymptomatic Bacteriuria+1 more
Barbara Trautner30 enrolled2 locationsNCT06559618
Recruiting
Phase 1Phase 2
Study Evaluating ABCL635 for Vasomotor Symptoms of Menopause
Healthy VolunteersVasomotor Symptoms Associated With Menopause
AbCellera Biologics Inc.136 enrolled13 locationsNCT07118891
Recruiting
Phase 1
Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmSymptomatic COVID-19 Infection Laboratory-Confirmed+4 more
M.D. Anderson Cancer Center30 enrolled1 locationNCT05101213
Recruiting
Phase 1Phase 2
Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmCOVID-19 Infection+2 more
M.D. Anderson Cancer Center70 enrolled1 locationNCT04565665
Recruiting
Phase 1
Open-Label Psilocybin Study in Transdiagnostic Population
AnxietyDepression - Major Depressive DisorderPTSD+5 more
Yale University50 enrolled1 locationNCT06442423
Recruiting
Phase 1Phase 2
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
MELAS SyndromeLebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
George Washington University24 enrolled1 locationNCT06792500
Recruiting
Phase 1
A Phase 1 Study of GTX-B001 in Healthy Subjects and Patients With Chronic Inducible Urticaria
Healthy SubjectsChronic Inducible UrticariaCold Urticaria+1 more
Granular Therapeutics Limited72 enrolled2 locationsNCT07181369
Recruiting
Phase 1
Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy
Persisting Symptoms After Concussion
University of Calgary40 enrolled1 locationNCT06615908
Recruiting
Phase 1Phase 2
Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Via Capsules for Intestinal Multidrug-resistant Bacteria Decolonization
Colonization, Asymptomatic
University of Rijeka48 enrolled1 locationNCT07106580
Recruiting
Phase 1
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
Mild Traumatic Brain InjuryHeadacheBrain Concussion+1 more
State University of New York - Upstate Medical University60 enrolled1 locationNCT06112093
Recruiting
Phase 1
Add-on MEmaNtine to Dopamine Modulation to Improve Negative Symptoms at First Psychosis
PsychosisNegative Symptoms With Primary Psychotic Disorder
Bjorn H. Ebdrup46 enrolled1 locationNCT04789915
Recruiting
Phase 1
A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
uncomplicated malariaAsymptomatic ConditionFalciparum; Malaria
Zydus Lifesciences Limited36 enrolled1 locationNCT05911828
Recruiting
Phase 1Phase 2
Combination Probiotic: BB-12 With LGG (Different Doses) in Treating Children With Autism Spectrum Disorder
Autism Spectrum DisorderGastrointestinal Symptoms
The University of Texas Health Science Center, Houston70 enrolled1 locationNCT03514784
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of 2-(diethylamino-N-(2,6-dimethylphenyl)acetamide 5% w/w trandermal patch against the innovator 32-(diethylamino-N-(2,6-dimethylphenyl)acetamide 5% w/w trandermal patch conducted under fasting conditions in healthy male and female volunteers.
2-(diethylamino-N-(2,6-dimethylphenyl)acetamide is used as a local anaesthetic. It is indicated for symptomatic relief of nerve pain associated with medically diagnosed post-herpetic neuralgia (post-shingles pain).
Zenith Technology Corporation Limited24 enrolled1 locationACTRN12622000141741
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of tamsulosin tablet against the innovator tamsulosin tablet conducted under fasting condition and at steady state in healthy male and female volunteers.
Tamsulosin is indicated for the relief of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).
Zenith Technology Corporation Limited24 enrolled1 locationACTRN12618001147279
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of tamsulosin tablet against the innovator tamsulosin tablet conducted under fed condition in healthy male and female volunteers.
Tamsulosin is indicated for the relief of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).
Zenith Technology Corp Ltd28 enrolled1 locationACTRN12618001051235
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of tamsulosin tablet against the innovator tamsulosin tablet conducted under fasting condition in healthy male and female volunteers.
Tamsulosin is indicated for the relief of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).
Zenith Technology Corporation Limited28 enrolled1 locationACTRN12618000776202
Completed
Phase 1
The effect of a dietary ketone on immunity, tolerability and performance in well-trained, healthy male cyclists.
Systemic symptoms (e.g. dizziness, nausea)Exercise-Induced immunosuppressionGastrointestinal distress
Auckland University of Technology12 enrolled1 locationACTRN12617001347358
Completed
Phase 1
The effect of a dietary ketone on immunity and tolerability in recreationally active, healthy males at rest.
Systemic symptoms (e.g. dizziness, nausea)Exercise-Induced immunosuppressionGastrointestinal distress
Auckland University of Technology6 enrolled1 locationACTRN12617000731392
Completed
Phase 1
Noribogaine Therapy for Relief of Opioid withdrawal, Phase 1B
Symptoms of opioid withdrawal
DemeRx Inc27 enrolled1 locationACTRN12613001064796