Phase 1 Tolerability Clinical Trials
15 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–15 of 15 trials
Recruiting
Phase 1
A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD)
SafetyTolerabilityAdult Growth Hormone Deficiency
Changchun GeneScience Pharmaceutical Co., Ltd.64 enrolled1 locationNCT07016802
Recruiting
Phase 1
A Study of GensSci098 in Subjects With Graves' Disease
SafetyGraves DiseaseTolerability+1 more
Changchun GeneScience Pharmaceutical Co., Ltd.24 enrolled1 locationNCT07286656
Recruiting
Phase 1
A Study of GenSci098 in Subjects With Active Thyroid Eye Disease
SafetyTolerabilityGenSci098+1 more
Changchun GeneScience Pharmaceutical Co., Ltd.76 enrolled1 locationNCT06569758
Recruiting
Phase 1Phase 2
Phase 1/2 Study of HYP-2090PTSA in Patients With Advanced Solid Tumors Harboring KRAS Mutation
EfficacySafetyTolerability
Sichuan Huiyu Pharmaceutical Co., Ltd257 enrolled6 locationsNCT06243354
Recruiting
Phase 1Phase 2
Phase 1/2 Clinical Study of HY07121 Powder for Solution for Infusion in Patients With Advanced Solid Tumors
EfficacySafetyTolerability
Sichuan Huiyu Pharmaceutical Co., Ltd258 enrolled1 locationNCT06639256
Recruiting
Phase 1
Safety, Tolerability, and Pharmacokinetics of RCS-21 in Healthy Volunteers.
SafetyHealthy VolunteersTolerability+1 more
RNATICS GmbH24 enrolled1 locationNCT06752122
Recruiting
Phase 1Phase 2
Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors
Safety IssuesTolerabilityPharmacokinetics
Nanjing Immunophage Biotech Co., Ltd196 enrolled7 locationsNCT05142592
Completed
Phase 1
Clinical trial investigating if anti-malaria treatment DSM265 causes an allergic reaction.
Tolerability of Anti-Malaria Vaccine
Medicines for Malaria Venture (MMV) - Non Profit Product Development Partnership11 enrolled1 locationACTRN12617000711314
Completed
Phase 1
A Phase I, Randomised, Open Label Study of the Safety, Tolerability and Pharmacokinetics of Single Sublingual or Oral Dose of GDN-1 in Adult Healthy Volunteers.
This trial is to assess the tolerability and pharmacokinetics in healthy adult volunteers and does not focus on any particular health condition or problem.
Subsequent studies are planned to evaluate efficacy in promoting improved exercise endurance and recovery, reduced muscle damage and soreness post exercise and for its lipid lowering effects in appropriate populations.
Gordagen Pharmaceuticals Pty Ltd60 enrolled1 locationACTRN12615000560594
Completed
Phase 1
A Randomized, Single-Blind, Single-Dose, 3-Arm, Parallel Group Study to Determine the Pharmacokinetic Equivalence of ABP 980 and Trastuzumab (Herceptin "(Registered Trademark)" ) in Healthy Male Subjects
To determine the safety, tolerability, and immunogenicity of ABP 980 in healthy subjects compared with FDA-licensed trastuzumab and EU-authorized trastuzumab.
Trastuzumab received marketing authorization in the EU in 2000 and is approved for use in patients with Breast Cancer and Metastatic Gastric Cancer.Breast Cancer
Amgen Inc, USA.150 enrolled1 locationACTRN12614000400662
Completed
Phase 1
A Single dose safety and tolerability study of oral noribogaine in healthy volunteers
Safety and tolerability study of oral noribogaine in Healthy Volunteer Participants
DemeRx, Inc.36 enrolled1 locationACTRN12612000821897
Recruiting
Phase 1
A Single-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Study to Evaluate the Safety and Tolerability of KDF-07002 in Healthy, Adult Volunteers
This trial is to assess safety and tolerability of KDF-07002 in healthy adult males and dose not focus on any particular health condition or problem
Nucleus Network, Ltd.54 enrolled1 locationACTRN12609000086268
Withdrawn
Phase 1
A single centre open-label study to evaluate the tolerability and safety of a synthetic injectable soft tissue implant material (Family C Matrix) in the skin of normal volunteers.
Tolerability & safety of a new synthetic soft tissue implant material.
Cosmetrend Pty Ltd14 enrolled1 locationACTRN12608000003370
Completed
Phase 1
Phase Ia Pharmacokinetic and Tolerability Study of Oral NV-27 in Normal Healthy Volunteers
Safety and tolerability of the investigational drug NV-27 in healthy male volunteers
Novogen Research Pty Ltd6 enrolled1 locationACTRN12607000611426
Withdrawn
Phase 1
A SINGLE CENTER OPEN-LABEL PILOT STUDY TO EVALUATE THE TOLERABILITY AND SAFETY OF A SYNTHETIC SOFT TISSUE IMPLANT MATERIAL IN THE SKIN OF NORMAL VOLUNTEERS
Tolerability and safety of a new synthetic soft tissue implant material for soft tissue augmentation in healthy volunteers.
COSMETREND PTY LTD8 enrolled1 locationACTRN12607000223437