Phase 1 Transplant Clinical Trials
67 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 67 trials
Recruiting
Phase 1Phase 2
The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation
Hematopoietic Stem Cell TransplantationPeripheral Blood Stem Cell Transplantation
National Cancer Institute (NCI)260 enrolled2 locationsNCT05436418
Recruiting
Phase 1Phase 2
Immunological Reset to Enable Access to Hla-compatible Kidney Transplantation in Highly Sensitized Patients (RESET)
Kidney TransplantationKidney Failure, ChronicAlloimmunization+3 more
Hospital Universitari Vall d'Hebron Research Institute10 enrolled1 locationNCT07607197
Recruiting
Phase 1Phase 2
Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
Sickle Cell DiseaseGraft FailureHematopoetic Stem Cell Transplant+2 more
Arkansas Children's Hospital Research Institute24 enrolled4 locationsNCT07252050
Recruiting
Phase 1Phase 2
Study to Evaluate the Safety and Efficacy of the GGTA1 KO Thymokidney in Patients With ESRD
Kidney TransplantationXenotransplantationESRD (End-Stage Renal Disease)
United Therapeutics50 enrolled1 locationNCT07224763
Recruiting
Phase 1
Treatment of Antibody-Mediated Rejection (ABMR) With CarBel
Kidney Transplant Rejection
National Institute of Allergy and Infectious Diseases (NIAID)25 enrolled10 locationsNCT06918990
Recruiting
Phase 1Phase 2
Polatuzumab Vedotin (Pola) Plus Rituximab (R) in Patients With Post-transplant Lymphoproliferative Disorder (PTLD)
Post-Transplant Lymphoproliferative Disorder
Washington University School of Medicine12 enrolled1 locationNCT06040320
Recruiting
Phase 1
CAR-T Cell Therapy for Desensitization in Kidney Transplantation
Kidney TransplantKidney FailureEnd Stage Renal Failure on Dialysis
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled3 locationsNCT06056102
Recruiting
Phase 1
CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma
Hematologic MalignancyRelapsed Pediatric ALLHematopoietic Cell Transplantation
St. Jude Children's Research Hospital70 enrolled1 locationNCT07257419
Recruiting
Phase 1Phase 2
Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor
Kidney TransplantToleranceRenal Transplant Rejection
Jeffrey Veale, MD15 enrolled1 locationNCT03707262
Recruiting
Phase 1
Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in Solid Organ Transplant Recipients
Solid Organ Transplant ComplicationsSolid Organ Transplant RecipientsSolid Organ Transplant Rejection
Francisco Hernández Oliveros10 enrolled1 locationNCT06997471
Recruiting
Phase 1
Eight-Treg Study:Trial of Adoptive Immunotherapy With Autologous ex Vivo Expanded Regulatory CD8+ T Cells in Living Donor Kidney Transplant Recipients
Kidney Transplantation
Nantes University Hospital9 enrolled1 locationNCT06777719
Recruiting
Phase 1
Alzheimer's Disease and Faecal Microbiota Transplantation -a Pilot Study
Alzheimer s DiseaseFaecal Microbiota Transplantation (FMT)
University Hospital of North Norway10 enrolled1 locationNCT07332260
Recruiting
Phase 1
EVR and EPO for Liver Transplant Tolerance
Liver Transplant
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled3 locationsNCT06832189
Recruiting
Phase 1
Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Graft
Acute LeukemiaMyelodysplastic SyndromesMyeloproliferative Disorders+3 more
Stanford University77 enrolled1 locationNCT05088356
Recruiting
Phase 1
Momelotinib During and After HCT in Myelofibrosis
MyelofibrosisHematopoietic Cell Transplantation (HCT)
Massachusetts General Hospital28 enrolled1 locationNCT07104799
Recruiting
Phase 1
Using T-Cell Alloreactivity and Chimerism to Guide Immunosuppression Minimization in Intestinal Transplantation
Intestinal Transplantation
Columbia University6 enrolled1 locationNCT04804891
Recruiting
Phase 1
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
Lung TransplantPulmonary Hypertension
Mayo Clinic4 enrolled1 locationNCT06770023
Recruiting
Phase 1Phase 2
Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With ESRD
Kidney TransplantationXenotransplantationESRD (End-Stage Renal Disease)
United Therapeutics50 enrolled2 locationsNCT06878560
Recruiting
Phase 1Phase 2
Immune Tolerance Induction After Liver Transplantation
Liver TransplantationEnd Stage Liver DiseaseImmune Tolerance+6 more
University of California, Los Angeles12 enrolled1 locationNCT07269041
Recruiting
Phase 1Phase 2
EBV-AST Cell Therapy for EBV-Related Diseases After Stem Cell Transplantation
Post-Transplant Lymphoproliferative DisorderEBV-DNA Viremia
Daihong Liu18 enrolled1 locationNCT07438067