Early Phase 1 Tumor Clinical Trials
79 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 79 trials
Recruiting
Early Phase 1
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
NeuroblastomaPineoblastomaAtypical Teratoid/Rhabdoid Tumor+11 more
C17 Council15 enrolled12 locationsNCT06942039
Recruiting
Early Phase 1
Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors
transitional cell carcinomaSoft Tissue SarcomaMelanoma+12 more
University of California, Irvine25 enrolled1 locationNCT07628634
Recruiting
Early Phase 1
A Window of Opportunity Trial of Mirdametinib Plus Vorinostat for NF1 Associated, H3K27 Trimethylation Deficient Malignant Peripheral Nerve Sheath Tumor [MPNST]
Primary Malignant Peripheral Nerve Sheath Tumors
University of Minnesota8 enrolled1 locationNCT06693284
Recruiting
Early Phase 1
AMT-676 in Patients With Advanced Solid Tumors
Advanced Solid Tumors
Multitude Therapeutics Inc.24 enrolled13 locationsNCT06400485
Recruiting
Early Phase 1
A IIT Study of 177Lu-DOTA-SNA040
Advanced Solid Tumors (Such as Gastric Cancer)Advanced Solid Tumors (Such as Adenocarcinoma at the Gastroesophageal Junction)Advanced Solid Tumors (Such as Pancreatic Cancer)+1 more
SmartNuclide Biopharma12 enrolled1 locationNCT07595237
Recruiting
Early Phase 1
Single Microdose Trial- CXCR4 PET Tracer - Pharmacokinetics and Pharmacodynamics of [68Ga]Ga-R54, a Radiopharmaceutical Directed Toward CXCR4 in Patients With Advanced Solid Neoplasia.
Advanced Solid TumorMultiple Myeloma
National Cancer Institute, Naples10 enrolled1 locationNCT07577206
Recruiting
Early Phase 1
Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors
Solid Tumor
St. Jude Children's Research Hospital25 enrolled3 locationsNCT05645523
Recruiting
Early Phase 1
SPH5030 Tablets in Subjects With Advanced Her2-positive Solid Tumors
HER2-Positive Advanced Solid Tumors
Shanghai Pharmaceuticals Holding Co., Ltd150 enrolled17 locationsNCT05245058
Recruiting
Early Phase 1
NK521 in the Treatment of Malignant Ascites Associated With Advanced Solid Tumors
Advanced Solid Tumors
Base Therapeutics (Shanghai) Co., Ltd.18 enrolled1 locationNCT07561437
Recruiting
Early Phase 1
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery
PainBrain InjuryBrain Tumors+3 more
University of Virginia40 enrolled1 locationNCT06810336
Recruiting
Early Phase 1
Study of Letrozole in Recurrent Gliomas
Brain Tumor
University of Cincinnati39 enrolled1 locationNCT03122197
Recruiting
Early Phase 1
Pencil Beam Scanning in Patients With Renal Tumors
Wilms TumorRenal Tumor
Children's Hospital of Philadelphia28 enrolled1 locationNCT03810651
Recruiting
Early Phase 1
Clinical Study on the Efficacy and Safety of CAR-DC in the Treatment of Advanced Solid Tumors
Advanced Solid Tumors
Peking University Shenzhen Hospital10 enrolled1 locationNCT07504445
Recruiting
Early Phase 1
Exploring the Clinical Value of RT01-89Zr PET Imaging in Solid Tumors
Solid Tumors
Nanolattix Biotechnology Co., Ltd.10 enrolled1 locationNCT07505069
Recruiting
Early Phase 1
Functionally Enhanced ALPP-Targeted Engineered T Cells in Advanced Solid Tumors
Solid Tumor
TCRCure Biopharma Ltd.24 enrolled1 locationNCT07487597
Recruiting
Early Phase 1
A Phase I Study to Evaluate the Safety, Tolerability, and PK of HLX37 in Advanced/Metastatic Solid Tumors
NSCLCAdvanced/Metastatic Solid Tumors
Shanghai Henlius Biotech254 enrolled2 locationsNCT07274813
Recruiting
Early Phase 1
A Single-Arm, Open-Label Clinical Study GK01 Cell Injection in Subjects With Advanced Solid Tumors.
Advanced Solid Tumors
Beijing Geekgene Technology Co., LTD10 enrolled1 locationNCT07414316
Recruiting
Early Phase 1
HEAT Trial (HER2 Antibody Therapy With Lutetium-177)
Advanced Solid TumorsHER2 Gene Mutation
Radiopharm Theranostics, Ltd30 enrolled5 locationsNCT06824155
Recruiting
Early Phase 1
B-GLUCANCER2 : A Pilot Study Evaluating a New Method for Cancer Detection by Measuring the Activity of Different Glycosidase Enzymes in the Plasma of Patients With a Localized Cancer.
Breast CancerPancreatic CancerPulmonary Cancer+4 more
Poitiers University Hospital220 enrolled1 locationNCT07236177
Recruiting
Early Phase 1
This is a Multi-Center Study of IBI3026 in Participants With Locally Advanced, Unresectable or Metastatic Solid Tumors
Solid Tumor
Innovent Biologics Technology Limited (Shanghai R&D Center)300 enrolled1 locationNCT07327632