Withdrawal Clinical Trials

36 recruitingLast updated: May 13, 2026

There are 36 actively recruiting withdrawal clinical trials across 11 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Baltimore, Maryland, United States, Philadelphia, Pennsylvania, United States, Indianapolis, Indiana, United States. Updated daily from ClinicalTrials.gov.


Withdrawal Trials at a Glance

36 actively recruiting trials for withdrawal are listed on ClinicalTrialsFinder across 6 cities in 11 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Baltimore, Philadelphia, and Indianapolis. Lead sponsors running withdrawal studies include Spark Biomedical, Inc., University of Maryland, Baltimore, and University of Pennsylvania.

Browse withdrawal trials by phase

Treatments under study

About Withdrawal Clinical Trials

Looking for clinical trials for Withdrawal? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Withdrawal trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Withdrawal clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 36 trials

Recruiting
Not Applicable

Neuroimaging of Adolescent Cannabis Use Treatment

Cannabis withdrawalSubstance Use DisordersCannabis Use+23 more
Indiana University80 enrolled1 locationNCT07340554
Recruiting
Not Applicable

The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments

Nicotine Dependence, CigarettesNicotine Withdrawal
Ottawa Heart Institute Research Corporation1,208 enrolled4 locationsNCT04163081
Recruiting
Phase 2

Evaluating Buspirone to Treat Opioid Withdrawal

AnxietyOpioid-use DisorderOpioid Withdrawal+1 more
University of Maryland, Baltimore100 enrolled1 locationNCT05511909
Recruiting
Phase 2

Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal

Chronic PainDrug Dependence of Morphine TypeSymptom, Withdrawal
University of Calgary40 enrolled1 locationNCT04939623
Recruiting
Not Applicable

tAN for Substance Use Disorder

Substance Use DisordersAlcohol Use DisorderAlcohol Abuse+1 more
Spark Biomedical, Inc.20 enrolled1 locationNCT07281261
Recruiting

Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

Opioid-use DisorderOpioid Withdrawal
Spark Biomedical, Inc.20 enrolled2 locationsNCT06487533
Recruiting
Not Applicable

Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients

AnxietyTobacco Use DisorderNicotine Dependence+2 more
Chiao-Chiao Liao60 enrolled1 locationNCT07466875
Recruiting
Phase 3

Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

Opioid UseOpioid-use DisorderWithdrawal Symptoms
Emory University103 enrolled6 locationsNCT05834478
Recruiting

CEDRN: Opioid Registry

Opioid-use DisorderOpioid WithdrawalPolysubstance Abuse+2 more
University of British Columbia7,200 enrolled1 locationNCT07466784
Recruiting

Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome

Neonatal Opioid Withdrawal Syndrome
HELP for NOWS Consortium796 enrolled22 locationsNCT07278375
Recruiting
Phase 2

Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal

Opioid UseOpiate Withdrawal Syndrome
University of Pennsylvania150 enrolled2 locationsNCT05995535
Recruiting

MicroRNA Biomarkers for Neonatal Opioid Withdrawal Syndrome

Neonatal Abstinence SyndromeNeonatal Opioid Withdrawal Syndrome
Milton S. Hershey Medical Center50 enrolled1 locationNCT05937594
Recruiting
Not Applicable

Motivational Interviews Post Hospitalisation on Maintaining AbstiNence for 1 Year après le Sevrage en Alcool

alcohol withdrawalRelapseAlcohol Use Disorder+2 more
University Hospital, Montpellier104 enrolled1 locationNCT06618755
Recruiting
Not Applicable

The Buzdar Technique

Chest Tube WithdrawalChest Tube ManagementIatrogenic Injury
University of Health Sciences Lahore300 enrolled1 locationNCT07338019
Recruiting

IWS Diagnosis Criteria Consensus

Iatrogenic Withdrawal Syndrome
ELIAS Emergency University Hospital120 enrolled1 locationNCT07316894
Recruiting
Phase 2

Prazosin for Alcohol Use Disorder With Withdrawal Symptoms

alcohol withdrawal
Yale University150 enrolled2 locationsNCT04793685
Recruiting
Phase 1Phase 2

ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain

Chronic PainOpioid Withdrawal
Medical University of South Carolina240 enrolled1 locationNCT06442566
Recruiting
Phase 3

Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)

Pregnancy ComplicationsOpioid-use DisorderPregnancy Related+2 more
Washington University School of Medicine40 enrolled1 locationNCT05790252
Recruiting
Phase 2Phase 3

Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

alcohol withdrawalKetosisAlcohol Use Disorder
University of Pennsylvania30 enrolled1 locationNCT06559995
Recruiting
Phase 2

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

Opioid-use DisorderOpioid WithdrawalOpioid Craving
University of Maryland, Baltimore60 enrolled1 locationNCT05027919