E-cigarette use Clinical Trials

12 recruitingLast updated: May 13, 2026

There are 12 actively recruiting e-cigarette use clinical trials across 3 countries. Studies span Not Applicable, Early Phase 1, Phase 1, Phase 2. Top locations include New Haven, Connecticut, United States, Charleston, South Carolina, United States, Iowa City, Iowa, United States. Updated daily from ClinicalTrials.gov.


E-cigarette use Trials at a Glance

12 actively recruiting trials for e-cigarette use are listed on ClinicalTrialsFinder across 6 cities in 3 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in New Haven, Charleston, and Iowa City. Lead sponsors running e-cigarette use studies include Yale University, Johns Hopkins University, and Anna Stanhewicz, PhD.

Browse e-cigarette use trials by phase

Treatments under study

About E-cigarette use Clinical Trials

Looking for clinical trials for E-cigarette use? There are currently 16 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new E-cigarette use trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about E-cigarette use clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Not Applicable

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

E-cigarette useTobacco UseHarm Reduction+1 more
Abramson Cancer Center at Penn Medicine200 enrolled1 locationNCT06372899
Recruiting
Not Applicable

Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing

E-cigarette useCigarette Smoking
Virginia Polytechnic Institute and State University70 enrolled1 locationNCT07161050
Recruiting
Not Applicable

An Online Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults

E-cigarette use
University of Southern California100 enrolled1 locationNCT06129123
Recruiting
Not Applicable

Adapting an Intervention for Vaping in Young Veterans

E-cigarette use
Veterans Medical Research Foundation20 enrolled1 locationNCT06196489
Recruiting
Phase 2

A Trial of Varenicline for E-cigarette Cessation

VapingE-cigarette useNicotine Dependence
Yale University326 enrolled2 locationsNCT07040566
Recruiting
Early Phase 1

Sex Differences in the Vascular Effects of E-cigarette Use

E-cigarette use
Anna Stanhewicz, PhD80 enrolled1 locationNCT06159608
Recruiting

Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers

E-cigarette use
Western University, Canada150 enrolled1 locationNCT04616313
Recruiting
Not Applicable

Vape-Free Text-Messaging: Pilot Study

E-cigarette use
Jovan Gwon, PhD, RN, FIAAN50 enrolled1 locationNCT05906082
Recruiting
Early Phase 1

Evaluation of the Electronic Cigarette Withdrawal Syndrome

E-cigarette useWithdrawal
Johns Hopkins University150 enrolled1 locationNCT06066996
Recruiting
Phase 1

Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use

E-cigarette useSmoking CessationCigarette Smoking
Yale University40 enrolled1 locationNCT06027840
Recruiting

Replication trial of the OurFutures Vaping Program: Evaluation of a school-based eHealth program to prevent e-cigarette use among adolescents in NSW Public Schools

E-cigarette useTobacco cigarette use
The University of Sydney1,265 enrolled1 locationACTRN12625000143426
Recruiting

Efficacy of a text-message based intervention in preventing adolescent e-cigarette use

E-cigarette use
University of Newcastle400 enrolled1 locationACTRN12623000079640