Topotecan Clinical Trials
35 recruitingDrug
Phase 320Phase 29Phase 18Phase 41Early Phase 11
Showing 1–20 of 35 trials
Recruiting
Phase 3
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
Ovarian NeoplasmsNeoplasm MetastasisFallopian Tube Neoplasms+1 more
Eli Lilly and Company1,630 enrolled266 locationsNCT07213804
Recruiting
Phase 2
N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma
NeuroblastomaHigh Risk NeuroblastomaChildhood Neuroblastoma
Memorial Sloan Kettering Cancer Center45 enrolled1 locationNCT06528496
Recruiting
Phase 3
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
Epithelial Ovarian Cancer
AstraZeneca1,100 enrolled299 locationsNCT07218809
Recruiting
Phase 3
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
NeuroblastomaGanglioneuroblastoma, Nodular
National Cancer Institute (NCI)478 enrolled178 locationsNCT06172296
Recruiting
Phase 3
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
Extensive-stage Small Cell Lung Cancer (ES-SCLC)
Gilead Sciences695 enrolled218 locationsNCT06801834
Recruiting
Phase 3
A Study to Investigate Mocertatug Rezetecan Compared With Standard of Care in Participants With Platinum-resistant Ovarian Cancer (BEHOLD-Ovarian01)
Ovarian Neoplasms
GlaxoSmithKline450 enrolled5 locationsNCT07286266
Recruiting
Phase 1Phase 2
A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)
Small Cell Lung Cancer ( SCLC )Extrapulmonary Neuroendocrine Carcinoma (EP-NEC)Neuroendocrine Carcinomas (NEC)+3 more
Phanes Therapeutics203 enrolled15 locationsNCT05652686
Recruiting
Phase 1Phase 2
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
Pediatric Cancer
Gustave Roussy, Cancer Campus, Grand Paris472 enrolled23 locationsNCT02813135
Recruiting
Phase 2
Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma
OsteosarcomaEwing Sarcoma
Milton S. Hershey Medical Center406 enrolled2 locationsNCT07321912
Recruiting
Phase 1
Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes
Metastatic Ewing Sarcoma
H. Lee Moffitt Cancer Center and Research Institute15 enrolled17 locationsNCT07194044
Recruiting
Phase 2Phase 3
A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Solid Cancer
Daiichi Sankyo860 enrolled152 locationsNCT06161025
Recruiting
Phase 1
Chronic CED of TPT for Recurrent Malignant Glioma
Brain Tumor, RecurrentMalignant Glioma (WHO Grade III or IV)IDH1/IDH2 Mutation
Jeffrey N. Bruce6 enrolled1 locationNCT06666712
Recruiting
Phase 1
Targeting Pediatric Brain Tumors and Relapsed/Refractory Solid Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i)
Pediatric Solid TumorPediatric Brain Tumor
Washington University School of Medicine20 enrolled1 locationNCT05521984
Recruiting
Phase 3
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
Small Cell Lung Cancer
Daiichi Sankyo540 enrolled232 locationsNCT06203210
Recruiting
Phase 1
Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer
Ovarian Cancer
Nerviano Medical Sciences24 enrolled5 locationsNCT06930755
Recruiting
Phase 3
A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC)
Neoplasms, Lung
GlaxoSmithKline420 enrolled120 locationsNCT07099898
Recruiting
Phase 2
Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer
Lung CancerNon-small Cell Lung CancerSmall Cell Lung Cancer
Fox Chase Cancer Center280 enrolled1 locationNCT05800587
Recruiting
Phase 3
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
Cervical Cancer
Merck Sharp & Dohme LLC686 enrolled240 locationsNCT06459180
Recruiting
Phase 3
Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma
Pleuropulmonary Blastoma
Children's Oncology Group110 enrolled82 locationsNCT06647953
Recruiting
Phase 2
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
Anaplastic Kidney Wilms TumorRecurrent Kidney Wilms TumorStage II Kidney Wilms Tumor+2 more
Children's Oncology Group256 enrolled204 locationsNCT04322318