University College London Hospitals NHS Foundation Trust
London, United Kingdom
27 recruiting
Showing 1–20 of 27 trials
Recruiting
Phase 2Phase 3
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
Advanced Non-Small Cell Lung CancerMetastatic Non Small Cell Lung Cancer
Mirati Therapeutics Inc.806 enrolled764 locationsNCT04613596
Recruiting
Phase 3
A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer
Low Grade Serous Ovarian Cancer
Verastem, Inc.270 enrolled106 locationsNCT06072781
Recruiting
Phase 2
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
Colorectal Cancer Stage IIIColorectal Cancer Stage II
BioNTech SE327 enrolled121 locationsNCT04486378
Recruiting
Phase 1
A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)
B-cell Non Hodgkin LymphomaRefractory B-Cell Non-Hodgkin LymphomaRelapsed B-Cell Non Hodgkin Lymphoma
ADC Therapeutics S.A.200 enrolled42 locationsNCT04970901
Recruiting
Phase 3
Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)
Leiomyosarcoma
PharmaMar450 enrolled94 locationsNCT06088290
Recruiting
Phase 3
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
CardiomyopathiesAmyloidosisHeart Diseases+3 more
Eidos Therapeutics, a BridgeBio company582 enrolled94 locationsNCT06563895
Recruiting
Phase 2
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
Parkinson DiseaseParkinsonParkinson Disease, Idiopathic+2 more
Neuron23 Inc.150 enrolled69 locationsNCT06680830
Recruiting
European Real-World Registry for Use of the Ion Endoluminal System
Lung CancerPulmonary Nodule
Intuitive Surgical1,200 enrolled5 locationsNCT06923774
Recruiting
Phase 3
Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations
Non-small Cell Lung CancerAdvanced Non-Small Cell Lung CancerMetastatic Non Small Cell Lung Cancer+3 more
ArriVent BioPharma, Inc.480 enrolled23 locationsNCT07185997
Recruiting
Phase 2
A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
MeiraGTx, LLC276 enrolled33 locationsNCT05926765
Recruiting
Phase 1
A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK
Alzheimer DiseaseAutosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder)Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder)+1 more
University College, London10 enrolled2 locationsNCT06372821
Recruiting
Phase 1
PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer
Royal Marsden NHS Foundation Trust45 enrolled9 locationsNCT04360941
Recruiting
Phase 4
VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease
Crohn DiseaseDisease CrohnModerately to Severely Active Crohn's Disease
Alimentiv Inc.304 enrolled69 locationsNCT06257706
Recruiting
Phase 1
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
Non-small Cell Lung Cancer
BioNTech SE280 enrolled45 locationsNCT05142189
Recruiting
Phase 3
A Randomised Controlled Platform Trial Testing Treatments in Metastatic Hormone Sensitive Prostate Cancer
Prostate Cancer Metastatic
University College, London3,360 enrolled18 locationsNCT06320067
Recruiting
Phase 2
Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer
Pancreatic Cancer
Cambridge University Hospitals NHS Foundation Trust20 enrolled13 locationsNCT05093231
Recruiting
Phase 1
POTENT - Tepotinib in Combination With Pembrolizumab in NSCLC
Non-small Cell Lung CancerAdvanced Cancer
Institute of Cancer Research, United Kingdom19 enrolled4 locationsNCT05782361
Recruiting
DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
Lung CancerPulmonary Nodule, SolitaryAI (Artificial Intelligence)+1 more
Nottingham University Hospitals NHS Trust2,000 enrolled10 locationsNCT05389774
Recruiting
Phase 1Phase 2
A Study of DSP-5336 in Relapsed/Refractory AML/ ALL With or Without MLL Rearrangement or NPM1 Mutation
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, Acute
Sumitomo Pharma America, Inc.362 enrolled92 locationsNCT04988555
Recruiting
TRAcking Thoracic Cancer Evolution Through Therapy (Rx) EVO
Lung Cancer (Non-Small Cell)Small Cell Lung CancerPleural Mesothelioma
University College, London600 enrolled1 locationNCT05628376