A randomised phase II study to evaluate the effectiveness of botulinum toxin to delay, and possibly prevent, progressive foot deformities in children with Charcot-Marie-Tooth (CMT) disease.

This study tests whether injections of botulinum toxin (similar to Botox) can slow down or prevent foot deformity in children with Charcot-Marie-Tooth disease (CMT), an inherited nerve condition. CMT can cause the foot to develop a high arch that gets worse over time. Researchers want to see if these injections can delay or prevent this problem. You may be eligible if: - Your child has been diagnosed with Charcot-Marie-Tooth disease type 1A - Your child has bilateral pes cavus (high arches in both feet) that is not yet fixed or rigid - The diagnosis has been confirmed clinically, and where possible with nerve tests or genetic testing You may NOT be eligible if: - There are no specific exclusion criteria listed for this study Talk to your doctor about whether this trial might be right for you.