The effects of nutritional supplementation on premenstrual syndrome

This study is testing whether daily calcium and magnesium supplements, with or without a multi-vitamin and herbal tablet, can reduce the symptoms of premenstrual syndrome (PMS). PMS causes physical and emotional symptoms (such as bloating, mood changes, and cramps) in the days before a period. Researchers also want to compare bone density between women with and without PMS. Women will take supplements daily for 4 months and report changes in their symptoms. You may be eligible if: - You are a female between 18 and 45 years old - You have a regular menstrual cycle of 25 to 35 days - You have had PMS symptoms in the last year - You are in generally good health - You are willing to stop taking other supplements for the duration of the study You may NOT be eligible if: - You are currently pregnant or breastfeeding - You are of childbearing age, not using effective contraception, and not willing to take monthly pregnancy tests - You are currently being treated for PMS - You have started or changed oral contraceptives within the last 3 months - You have a thyroid, parathyroid, or mood disorder - You have a significant health condition - You are under a lot of stress or experiencing serious relationship problems Talk to your doctor about whether this trial might be right for you.