Evaluation of new drug treatments including artemisinin combination therapy for uncomplicated malaria in children in Papua New Guinea

This study is testing new combination treatments for malaria in children in Papua New Guinea. Malaria is caused by parasites spread by mosquitoes and is a major health problem in PNG. Researchers are looking at whether new drug combinations based on artemisinin drugs (a powerful and fast-acting treatment) and piperaquine (a related drug) work better than existing treatments in children with uncomplicated malaria. You may be eligible if: - Your child is between 4 and 10 years old - Your child has a fever and a blood test has confirmed malaria (P. falciparum or P. vivax) - Your child does not have severe malaria - Your child has not taken antimalarial drugs recently (quinine or artemisinin in the last 7 days, or related drugs in the last 28 days) - There is no other obvious cause of the fever - A parent or guardian is able to give informed consent You may NOT be eligible if: - There are no additional exclusion criteria listed beyond the inclusion requirements Talk to your doctor about whether this trial might be right for you.