Malaria Clinical Trials

85 recruitingLast updated: June 18, 2026

There are 85 actively recruiting malaria clinical trials across 45 countries. Studies span Phase 4, Phase 3, Phase 2, Phase 1, Not Applicable. Top locations include Bamako, Mali, Kisumu, Kenya, Nanoro, Burkina Faso. Updated daily from ClinicalTrials.gov.


Malaria Trials at a Glance

85 actively recruiting trials for malaria are listed on ClinicalTrialsFinder across 6 cities in 45 countries. The largest study group is Phase 4 with 23 trials, with the heaviest enrollment activity in Bamako, Kisumu, and Nanoro. Lead sponsors running malaria studies include National Institute of Allergy and Infectious Diseases (NIAID), University of Oxford, and Liverpool School of Tropical Medicine.

Browse malaria trials by phase

Treatments under study

About Malaria Clinical Trials

Looking for clinical trials for Malaria? There are currently 164 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Malaria trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Malaria clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 85 trials

Recruiting

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Sickle Cell DiseaseMalariaAlpha and Beta Thalassemia+1 more
National Institute of Allergy and Infectious Diseases (NIAID)300 enrolled1 locationNCT03937817
Recruiting
Phase 1

Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Combination With MMV371 in Healthy Participants

Malaria,Falciparum
Medicines for Malaria Venture72 enrolled1 locationNCT07011511
Recruiting
Phase 1

Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding Assays

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)300 enrolled1 locationNCT06607003
Recruiting
Phase 3

FocaL Mass Drug Administration for Vivax Malaria Elimination

Plasmodium Vivax MalariaMalaria
University of California, San Francisco7,530 enrolled1 locationNCT05690841
Recruiting

Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)1,500 enrolled1 locationNCT02639299
Recruiting

Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)15,000 enrolled2 locationsNCT01168271
Recruiting
Phase 2

Field Trial of PfSPZ-LARC2 Vaccine in Burkinabe Adults

Malaria (Plasmodium Falciparum)
Sanaria Inc.180 enrolled1 locationNCT07385287
Recruiting

Laboratory Evaluation of Pregnancy Malaria Vaccine Candidates/In-vitro Testing of Pregnancy Malaria Vaccine Candidates

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)7,476 enrolled1 locationNCT02471378
Recruiting
Phase 2

Infant Malaria Vaccine Schedule Optimization

Malaria Vaccines
PATH964 enrolled2 locationsNCT06879327
Recruiting
Phase 2

Safety and Efficacy of Imatinib in Combination With Artemether-Lumefantrine for Uncomplicated Malaria

Malaria (Plasmodium Falciparum)
Victoria Biomedical Research Institute1,116 enrolled1 locationNCT07559370
Recruiting
Phase 1

Safety, Tolerability and Efficacy Against Controlled Human Malaria Infection of PfSPZ-LARC2 Vaccine in Malaria-naïve Adults

Malaria,Falciparum
Sanaria Inc.58 enrolled1 locationNCT06862453
Recruiting
Phase 4

Comparison of Two Strategies for Administering the R21-Matrix M Vaccine in a Context of Seasonal Malaria Transmission in Chad

Malaria infectionMalaria Vaccines
Epicentre70,000 enrolled1 locationNCT07038837
Recruiting
Phase 1

A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants

Malaria,Falciparum
GlaxoSmithKline156 enrolled1 locationNCT06171113
Recruiting
Phase 3

Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar

Malaria,FalciparumMalaria, VivaxPlasmodium Vivax+1 more
London School of Hygiene and Tropical Medicine19,200 enrolled2 locationsNCT06923592
Recruiting

Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic Infection

MalariaIntestinal WormsGI Protozoa+2 more
National Institute of Allergy and Infectious Diseases (NIAID)800 enrolled1 locationNCT00001645
Recruiting

Pregnancy Registry in Mali

MalariaPregnancy Related
National Institute of Allergy and Infectious Diseases (NIAID)9,500 enrolled1 locationNCT06468319
Recruiting
Phase 1

A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 Combined With R21/Matrix-M (a "Multi-stage" Malaria Vaccine)

Malaria,Falciparum
University of Oxford56 enrolled1 locationNCT06958198
Recruiting
Phase 4

Primaquine for Vivax Malaria in G6PD Intermediate and Deficient Cases.

Vivax malariaG6PD Deficiency
Menzies School of Health Research100 enrolled4 locationsNCT07468513
Recruiting
Phase 2

Dose Finding Trial of R21/Matrix-M in School Children

Malaria (Plasmodium Falciparum)
University of Oxford40 enrolled1 locationNCT07074665
Recruiting
Phase 2

L9LS in Women of Childbearing Potential in Mali

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)290 enrolled3 locationsNCT07060508