Malaria Clinical Trials

163 recruiting

Malaria Trials at a Glance

73 actively recruiting trials for malaria are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Phase 4 with 20 trials, with the heaviest enrollment activity in Bamako, Bethesda, and Kisumu. Lead sponsors running malaria studies include National Institute of Allergy and Infectious Diseases (NIAID), University of Oxford, and Liverpool School of Tropical Medicine.

Browse malaria trials by phase

Treatments under study

About Malaria Clinical Trials

Looking for clinical trials for Malaria? There are currently 163 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Malaria trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Malaria clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 73 trials

Recruiting

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Sickle Cell DiseaseMalariaAlpha and Beta Thalassemia+1 more
National Institute of Allergy and Infectious Diseases (NIAID)300 enrolled1 locationNCT03937817
Recruiting
Phase 1

Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding Assays

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)300 enrolled1 locationNCT06607003
Recruiting

Laboratory Evaluation of Pregnancy Malaria Vaccine Candidates/In-vitro Testing of Pregnancy Malaria Vaccine Candidates

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)7,476 enrolled1 locationNCT02471378
Recruiting

Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)1,500 enrolled1 locationNCT02639299
Recruiting
Phase 2

Safety and Efficacy of Imatinib in Combination With Artemether-Lumefantrine for Uncomplicated Malaria

Malaria (Plasmodium Falciparum)
Victoria Biomedical Research Institute1,116 enrolled1 locationNCT07559370
Recruiting

Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)15,000 enrolled2 locationsNCT01168271
Recruiting

Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic Infection

MalariaIntestinal WormsGI Protozoa+2 more
National Institute of Allergy and Infectious Diseases (NIAID)800 enrolled1 locationNCT00001645
Recruiting

Pregnancy Registry in Mali

MalariaPregnancy Related
National Institute of Allergy and Infectious Diseases (NIAID)9,500 enrolled1 locationNCT06468319
Recruiting
Phase 1

A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 Combined With R21/Matrix-M (a "Multi-stage" Malaria Vaccine)

Malaria,Falciparum
University of Oxford56 enrolled1 locationNCT06958198
Recruiting
Phase 2

Dose Finding Trial of R21/Matrix-M in School Children

Malaria (Plasmodium Falciparum)
University of Oxford40 enrolled1 locationNCT07074665
Recruiting
Phase 2

L9LS in Women of Childbearing Potential in Mali

Malaria
National Institute of Allergy and Infectious Diseases (NIAID)290 enrolled3 locationsNCT07060508
Recruiting

Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-typhoidal Salmonella Disease

MalariaMalaria VaccineInvasive Non-Typhoidal Salmonella Disease
International Vaccine Institute10,000 enrolled1 locationNCT07416461
Recruiting
Phase 4

OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa

Malaria
Yale University380 enrolled2 locationsNCT06967519
Recruiting
Not Applicable

Assessing the Feasibility of Combining Dihydroartemisinin Piperaquine and Primaquine for Malaria Mass Drug Administration in High Endemic Communities in the Eastern Region of Ghana

Malaria Asymptomatic Parasitaemia
Noguchi Memorial Institute for Medical Research9,000 enrolled1 locationNCT07389057
Recruiting
Phase 4

Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics

PregnancyMalaria,FalciparumMalaria in Pregnancy+1 more
Duke University2,500 enrolled2 locationsNCT05757167
Recruiting

Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective

Streptococcus PneumoniaeMalariaMeningitis+55 more
Institut Pasteur du Cambodge10,000 enrolled1 locationNCT07358910
Recruiting

Introduction of Polymerase Chain Reaction (PCR) in Microbiology and Parasitology

Malaria, Pneumocystis, Leishmania
Fondazione IRCCS Policlinico San Matteo di Pavia200 enrolled1 locationNCT07269314
Recruiting
Phase 4

PDMC Implementation Trial in Kenya

Severe MalariaSevere Anemia
Liverpool School of Tropical Medicine600 enrolled1 locationNCT06624631
Recruiting
Phase 3

Safety of Antimalarials in the FIRst trimEster

Malaria, PregnancyMalaria, AntepartumMalaria (Uncomplicated)
Liverpool School of Tropical Medicine1,510 enrolled3 locationsNCT06962319
Recruiting
Phase 2

Pfs230D1 + R21 in Matrix-M1 in African School Children and Adults

Prevention of Malaria Transmission and Clinical Malaria
Serum Institute of India Pvt. Ltd.1,200 enrolled1 locationNCT07147400