RecruitingACTRN12606000352505

The use of D-Cycloserine in combination with exposure therapy to treat social anxiety

A randomised controlled trial to evaluate the effect of D-Cycloserine in combination with exposure therapy in the treatment of social phobia to improve the severity of social phobia symptoms


Sponsor

University of New South Wales

Enrollment

40 participants

Start Date

May 20, 2006

Study Type

Interventional

Conditions

Summary

This study tests whether d-cycloserine improves the effectiveness of exposure therapy for decreasing social anxiety symptoms. We predict that individuals from the community diagnosed with social phobia who receive four exposure therapy sessions in comdination with D-Cycloserine will experience a greater reduction in social anxiety symptoms than individuals who receive placebo in combination with four exposure therapy sessions. Participants receive five weekly group therapy sessions. the first session is educational and the next four consist of public speaking exposure therapy. One month post intervention participants are assessed for social anxiety symptoms as well as other general health indicators. All subjects, therapists, assessors and data entry research staff are blind to condition.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether a drug called D-Cycloserine can make exposure therapy more effective for people with social anxiety (social phobia). Social phobia is an intense fear of being judged or embarrassed in social situations, and it can make everyday activities like talking to people or speaking in public very difficult. Exposure therapy helps by having you gradually face these feared situations. D-Cycloserine may help the brain let go of fear more quickly. Participants will take D-Cycloserine or a placebo pill before group therapy sessions involving public speaking practice, and their anxiety levels will be measured one month later. You may be eligible if: - You are 18 years of age or older - Your primary (main) diagnosis is social phobia (social anxiety disorder) You may NOT be eligible if: - You have epilepsy - You have severe kidney disease - You have thoughts of suicide - You have a substance dependence problem - You are taking medications that cannot be used with D-Cycloserine - You are pregnant Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Participants with social phobia are given exposure therapy over 5 once per week weekly treatment sessions in combination with D-cycloserine (50mg) in capsule form to be swallowed orally. Exposure ther

Participants with social phobia are given exposure therapy over 5 once per week weekly treatment sessions in combination with D-cycloserine (50mg) in capsule form to be swallowed orally. Exposure therapy consists of 3 to 10 minute speech tasks in front of a group (some decrease in anxiety should be observed).


Locations(1)

Australia

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