RecruitingACTRN12606000352505

The use of D-Cycloserine in combination with exposure therapy to treat social anxiety

A randomised controlled trial to evaluate the effect of D-Cycloserine in combination with exposure therapy in the treatment of social phobia to improve the severity of social phobia symptoms


Sponsor

University of New South Wales

Enrollment

40 participants

Start Date

May 20, 2006

Study Type

Interventional

Conditions

Summary

This study tests whether d-cycloserine improves the effectiveness of exposure therapy for decreasing social anxiety symptoms. We predict that individuals from the community diagnosed with social phobia who receive four exposure therapy sessions in comdination with D-Cycloserine will experience a greater reduction in social anxiety symptoms than individuals who receive placebo in combination with four exposure therapy sessions. Participants receive five weekly group therapy sessions. the first session is educational and the next four consist of public speaking exposure therapy. One month post intervention participants are assessed for social anxiety symptoms as well as other general health indicators. All subjects, therapists, assessors and data entry research staff are blind to condition.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Inclusion Criteria1

  • Primary diagnosis of Social Phobia.

Exclusion Criteria1

  • Epilepsy, severe kidney disease, Suicide intent, substance dependence, use of contra-inidcated medications, pregnancy.

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Interventions

Participants with social phobia are given exposure therapy over 5 once per week weekly treatment sessions in combination with D-cycloserine (50mg) in capsule form to be swallowed orally. Exposure ther

Participants with social phobia are given exposure therapy over 5 once per week weekly treatment sessions in combination with D-cycloserine (50mg) in capsule form to be swallowed orally. Exposure therapy consists of 3 to 10 minute speech tasks in front of a group (some decrease in anxiety should be observed).


Locations(1)

Australia

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