RecruitingACTRN12607000256471

The use of Oxytocin in combination with exposure therapy to treat social anxiety symptoms.

A randomised controlled trial to evaluate the effect of Oxytocin (OT; 24 IU) in combination with exposure therapy for the treatment of social phobia to improve the severity of social phobia symptoms.


Sponsor

University of New South Wales

Enrollment

40 participants

Start Date

Feb 1, 2007

Study Type

Interventional

Conditions

Summary

This study tests whether Oxytocin improves the effectiveness of exposure therapy for decreasing social anxiety symptoms. We predict that individuals from the community diagnosed with social phobia who receive four exposure therapy sessions in combination with Oxytocin will experience a greater reduction in social anxiety symptoms in comparison to individuals who received the placebo in combination with four exposure therapy sessions. Participants receive, in total, five weekly group therapy sessions, the first is educational and the next four consist of public speaking exposure therapy. One month post intervention participants are assessed for social anxiety symptoms as well as other general health indicators. All subjects, therapists, assessors, and data entry staff are blind to condition.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether a nasal spray containing oxytocin — sometimes called the 'trust hormone' — can make therapy more effective for people with social anxiety (also called social phobia). Social anxiety involves strong fear of social situations, especially public speaking or being judged by others. Participants take part in five weekly group therapy sessions focused on public speaking practice. Some participants receive oxytocin before the sessions, and others receive a placebo (dummy spray). Neither participants nor therapists know who gets which. Researchers will measure anxiety symptoms before and after the program. You may be eligible if: - You are a university student aged 18 or older - You have been diagnosed with social phobia You may NOT be eligible if: - You are under 18 years of age - You are pregnant - You have epilepsy - You have a problem with drug or alcohol use - You have psychotic symptoms - You have thoughts of self-harm or suicide - You are unable to avoid alcohol, caffeine, or illegal drugs on the days oxytocin is administered Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Participants with social phobia are given group exposure based therapy over 5 weekly treatment sessions in combination with a Nasal Spray dose of Oxytocin (OT; 24 IU). Exposure therapy consists of 3 t

Participants with social phobia are given group exposure based therapy over 5 weekly treatment sessions in combination with a Nasal Spray dose of Oxytocin (OT; 24 IU). Exposure therapy consists of 3 to 10 minute speech tasks in front of a group where a decrease in anxiety within this situation is observed.


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ACTRN12607000256471


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