RecruitingPhase 4ACTRN12606000355572

Effect of barley foods on cardiovascular health biomarkers

A randomised cross-over study of the effects of barley foods containing beta-glucans compared with whole wheat foods on cardiovascular health biomarkers, total cholesterol, HDL cholesterol, LDL cholesterol & triglycerides in people with hypercholesterolaemia


Sponsor

Commonwealth Scientific Industrial Research Organisation, Human Nutrition

Enrollment

30 participants

Start Date

Aug 21, 2006

Study Type

Interventional

Conditions

Summary

To discover if the consumption of foods made from CSIRO barley leads to changes in the levels of substances in the plasma (such as cholesterol) that would suggest they are beneficial for heart health.


Eligibility

Sex: Both males and femalesMin Age: 30 YearssMax Age: 75 Yearss

Plain Language Summary

Simplified for easier understanding

This study is looking at whether eating foods made from a special type of barley developed by the CSIRO can improve heart health. Barley contains a type of fibre that may help lower cholesterol and triglycerides (fats in the blood), both of which are linked to heart disease. Participants will eat barley-based foods as part of their normal diet and have blood tests to see if their cholesterol and other heart-related markers improve. The study will compare results when eating barley foods against a control period. You may be eligible if: - You are between 30 and 75 years old - Your blood triglycerides are between 1.7 and 4.0 mmol/L, and/or your total cholesterol is above 5.5 mmol/L - If you are taking cholesterol-lowering medication, the dose must remain the same throughout the study You may NOT be eligible if: - You have a known allergy or intolerance to barley or wheat (such as coeliac disease) - You have a bleeding disorder - You have a history of gut, kidney, or liver disease - You have participated in another study in the past 30 days - You are taking medications that affect cholesterol (such as psyllium laxatives, antibiotics, probiotics, or plant sterol margarines) Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

All participants at the start of the study will be on a fat controlled diet for 2 week prior to being randomised to 1 of 2 treatments of 6 weeks duration each & crossed over at the end of each 6 weeks

All participants at the start of the study will be on a fat controlled diet for 2 week prior to being randomised to 1 of 2 treatments of 6 weeks duration each & crossed over at the end of each 6 weeks to the alternative. The treatments are either test foods (cereal, bread muffins) containing either barley flour or wholemeal wheat flour. There is no wash-out period between treatments.


Locations(1)

Australia

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ACTRN12606000355572


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