NicoNovum Evaluation of Withdrawal Relief Study Part 2

This study tests new nicotine replacement products — a nicotine mouth spray and a nicotine lozenge — to see how quickly and effectively they relieve the discomfort people feel when they stop smoking (withdrawal symptoms). These new products are compared to nicotine gum (an existing product) and a dummy product with no nicotine. The study also asks how satisfied people feel after using each product. Faster nicotine delivery might better ease the urge to smoke. You may be eligible if: - You are between 18 and 70 years old - You smoke at least 15 cigarettes per day and have done so for at least one year - You usually smoke within 30 minutes of waking up - You are in generally good health - You can attend the study site on the same day each week for 4 weeks - You can read and write in English You may NOT be eligible if: - You have had a heart attack, angina, or serious illness in the last 6 months - You have diabetes - You have a current psychiatric disorder - You are pregnant or breastfeeding - You weigh less than 45 kg or more than 120 kg - You have high blood pressure (above 180/100 mmHg) - You currently use nicotine products other than cigarettes - You take certain medications including clonidine, bupropion, or other psychotropic drugs Talk to your doctor about whether this trial might be right for you.