The effect of bronchodilators on lung ventilation in chronic obstructive pulmonary disease
The effect of tiotropium bromide on ventilation perfusion heterogeneity in chronic obstructive pulmonary disease
The Woolcock Institute of Medical Research
15 participants
Aug 4, 2007
Interventional
Conditions
Summary
Chronic Obstructive Pulmonary Disease (COPD) is a common disorder which causes changes within the airways and blood vessels of the lung. As a result of these changes, it can cause problems with breathing and the way air and oxygen travels to different parts of the lung. We have several different ways of looking at how bad COPD is, however none of these are perfect. By understanding better the way in which airways behave in COPD, and the effects this has on blood flow within the lung, the better able we will be to investigate, develop new medications, and treat COPD. In this study we will be investigating the way COPD affects breathing and blood flow by looking at changes in lung function. We will then compare this information with pictures of breathing and blood flow obtained from a nuclear medicine scan.
Eligibility
Inclusion Criteria2
- Subjects must have a doctor diagnosis of COPD, greater than 15pack year smoking history and obstructed lung function that cannot be normalised with bronchodilator. Subjects must all be over the age of 50 with no history of asthma or allergic disease.
- Minimum age: 50 years for females and 40 years for males
Exclusion Criteria1
- Females under the age of 50years
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Interventions
Washout period is one week between interventions. Single dose of 18µg tiotropium bromide and 200µg salbutamol. Both drugs are inhaled
Locations(1)
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ACTRN12607000482460