Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

This trial tests a device called the dNerva Lung Denervation System, which uses a bronchoscope (a thin flexible tube passed through the mouth) to disrupt the lung nerves that contribute to excessive mucus production, coughing, and airway tightening in people with moderate-to-severe COPD (chronic obstructive pulmonary disease). **You may be eligible if:** - You are between 40 and 80 years old - You have smoked for at least 10 pack-years and have not smoked for at least 2 months - You have confirmed moderate-to-severe COPD (based on breathing tests) - You have significant breathlessness (MMRC score ≥ 2) and symptoms (CAT score ≥ 10) - You are already on standard COPD medications - You have significant air trapping in your lungs - Your oxygen level at rest is at least 89% **You may NOT be eligible if:** - Your BMI is below 18 or above 32 - You have had 4 or more hospitalizations for breathing problems in the past year - You have a condition other than COPD driving your lung symptoms (e.g., cystic fibrosis, asthma, interstitial lung disease) - You have pulmonary hypertension or serious heart disease - You have had recent stomach or esophageal surgery - You are currently in another clinical trial Talk to your doctor to see if this trial is right for you.