CompletedPhase 2Phase 3ACTRN12607000588493

Evaluation of Tafenoquine for the Post-Exposure Prophylaxis of Vivax Malaria (Southwest Pacific Type) in Non-Immune Australian Soldiers

Comparison of three different dose regimens of tafenoquine versus primaquine for post-exposure prophylaxis of Plasmodium vivax malaria in the Southwest Pacific.

Sponsor

GlaxoSmithKline

Enrollment

600 participants

Start Date

Feb 1, 1999

Study Type

Interventional

Conditions

Malaria

Summary

Assessment of various tafenoquine dose regimens to determine the most effective dose for post exposure prophylaxis of P.vivax malaria in the Southwest Pacific

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 55 Yearss

Plain Language Summary

Simplified for easier understanding

This study is about evaluation of Tafenoquine for the Post-Exposure Prophylaxis of Vivax Malaria (Southwest Pacific Type) in Non-Immune Australian Soldiers. It is looking for adults aged 18 to 55 to participate. To join, participants should meet requirements such as: Glucose-6-Phosphate Dehydrogenase (G6PD) normal,. Participants will be guided through the study procedures by the research team and may need to attend scheduled visits.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Comparison of different tafenoquine regimens for tolerability and efficacy of malaria prevention. Tafenoquine doses of 400mg once daily, 200mg twice daily and 200mg once daily were given to volunteer

Comparison of different tafenoquine regimens for tolerability and efficacy of malaria prevention. Tafenoquine doses of 400mg once daily, 200mg twice daily and 200mg once daily were given to volunteers orally for 3 days prior to departure from a malarious area.

Locations(1)

Australia

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ACTRN12607000588493

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