RecruitingACTRN12608000059369

A structural and functional imaging research of children with Attention Deficit Hyperactivity Disorder (ADHD)

Structural and functional imaging maps of children with Attention Deficit Hyperactivity Disorder (ADHD) using Magnetic Resonance Imaging (MRI) scan of the brain and methylphenidate (MPH)


Sponsor

Children Psychiatry Department, Institute of Mental Health, Peking University

Enrollment

30 participants

Start Date

Aug 21, 2007

Study Type

Interventional

Conditions


Eligibility

Sex: MalesMin Age: 11 YearssMax Age: 16 Yearss

Plain Language Summary

Simplified for easier understanding

This study is using brain imaging (MRI and other scans) to look at the structure and function of the brain in boys with Attention Deficit Hyperactivity Disorder (ADHD). ADHD causes problems with attention, impulse control, and sometimes hyperactivity. By comparing brain scans of boys with ADHD to those without, researchers hope to better understand what is happening in the brain and how it relates to the symptoms of ADHD. You may be eligible if: - You are a boy between 11 and 16 years of age - You have been diagnosed with ADHD according to standard diagnostic criteria (DSM-IV) - You have an IQ score of 80 or higher You may NOT be eligible if: - You are left-handed - You have a history of head injury with loss of consciousness - You have a neurological illness (such as epilepsy) - You have another psychiatric diagnosis such as schizophrenia, anxiety disorder, Tourette syndrome, autism, or intellectual disability Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

All participants will be scanned by a MRI scanner. The total time of a scan session is about 45 minutes and data of structural and functional images of the subjects’ brains will be collected. In the f

All participants will be scanned by a MRI scanner. The total time of a scan session is about 45 minutes and data of structural and functional images of the subjects’ brains will be collected. In the functional part, the subjects will perform a cognitive task. Children with ADHD will be scanned twice. About 1 hour before one of the scan sessions, the patients will take a single dose (10 mg) of MPH orally, which is a drug commonly used in the treatment of ADHD. Then the patients will be scanned. (About 1 hour before the other scan session, the patients will take the placebo, which is described in the “Comparator / control treatment” part of the form.) The order of the two sessions will be counterbalanced across the patients. The interval between the two sessions will be about 1 week, which is thought to be enough for the clearance of the drug.


Locations(1)

China

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ACTRN12608000059369


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