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RecruitingACTRN12609001055291

Real-time humidity measurements of expired breathe in non-invasive ventilation.

Randomised, cross-over comparison of humidifying load imposed on the human airway under different conditions of inspired gas in a noninvasive setting.

Sponsor

Fisher & Paykel Healthcare

Enrollment

10 participants

Start Date

Nov 6, 2008

Study Type

Interventional

Conditions

Respiratory function

Summary

This study is to evaluate the humidifying load imposed on the human airway by inspired gas at various temperatures and humidities. The humidity response of the volunteers are measured in real-time using the infrared laser hygrometer developed by Fisher & Paykel Healthcare Ltd. (FPH).

Eligibility

Sex: MalesMin Age: 20 YearssMax Age: 35 Yearss

Plain Language Summary

Simplified for easier understanding

This study is measuring how the body's airways handle different levels of humidity and temperature in breathed-in air. A special laser device is used to measure moisture in the air you breathe out in real time. The goal is to better understand how medical devices like breathing machines should deliver humidified air to patients. You may be eligible if: - You are a healthy male - You are between 20 and 35 years old - You are willing to give your consent to participate You may NOT be eligible if: - You have cystic fibrosis - You have any respiratory (breathing) disease Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

12 different conditions of inspired air (treatments) will be supplied to the volunteers ranging from dry air at room temperature to saturated air at 40 degC. Each participant will receive all the trea

12 different conditions of inspired air (treatments) will be supplied to the volunteers ranging from dry air at room temperature to saturated air at 40 degC. Each participant will receive all the treatments in a randomised order. Different conditions are: 1. 25 degC and 0% Relative Humidity (RH) 2. 25 degC and 100% RH 3. 28 degC and 100% RH 4. 32 degC and 0% RH 5. 32 degC and 100% RH 6. 37 degC and 0% RH 7. 37 degC and 50% RH 8. 37 degC and 100% RH 9. 40 degC and 0% RH 10. 40 degC and 50% RH 11. 40 degC and 100% RH For each of the gas condition, the volunteers are asked to breathe with three different rates that are controlled by a digital blinker written in LabVIEW and a stop watch. Humidity output between oral and nasal breathing will also be studied. Each treatment will last 30 minutes and includes all 3 respiratory rates on both oral and nasal breathing. 24 hours recovering period are given between each treatment. The study will run for 2 months and there will be no follow-up on the participants.

Locations(1)

New Zealand

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