LoDoCo - VRIC Low Dose Colchicine in stable coronary artery disease, Vascular Reactivity and the Inflammatory Cascade.

This study is testing whether low-dose colchicine — a medication usually used for gout — can reduce inflammation and improve blood vessel function in people with stable coronary artery disease (heart disease). Inflammation plays a key role in the buildup of plaques in heart arteries, and colchicine may help by calming this inflammation. Researchers will measure blood vessel flexibility and inflammatory markers in the blood. You may be eligible if: - You are between 18 and 80 years old - You have confirmed coronary artery disease (proven by angiogram showing significant blockage, or you have had a stent procedure) - Your condition has been stable for at least 1 month - You have no contraindications to colchicine You may NOT be eligible if: - Your coronary artery disease is not stable, or only mild - You have advanced heart failure (NYHA grade 3 or 4) - You have severe kidney disease or known cancer - You have inflammatory bowel disease - You are taking cyclosporine or other medications that interact with colchicine - You are pregnant or planning to become pregnant during the study Talk to your doctor about whether this trial might be right for you.