Immune response to two-dose fractional inactivated poliovirus vaccine administered at 4- and 8- month of age
Immune response and seroconversion in two-dose fractional inactivated poliovirus vaccine administered at 4 and 8 months of age
World Health Organization
320 participants
Jul 1, 2009
Interventional
Conditions
Summary
The purpose of this study is to test the efficacy of a two dose schedule using either fractional or full dose IPV with the ultimate purpose to find a way for developing countries to adopt more affordable IPV use strategies in the future. It is hypothesized the fractional dose arm will be non-inferior to the full dose arm.
Eligibility
Inclusion Criteria2
- Healthy infants (greater than 3rd percentile for height and weight) at enrollment living within the catchment area of
- the participating polyclinics.
Exclusion Criteria5
- Infants less than 3 percentile for height and weight, residence outside the catchment area, or families expecting
- to move away during the study period, will be excluded. A diagnosis, suspicion or treatment of
- immunodeficiency disorder (either in the participant or in a member of the immediate family) will render
- the newborn ineligible for the study. Infants of mother age below legal age (<18 years) or with mentally
- incapacity will not be eligible to participate.
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Interventions
Two fractional 0.1 ml IPV doses administered intradermally at 4 and 8 month old infants
Locations(1)
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ACTRN12610001046099