RecruitingACTRN12611000149965

Acupuncture for treatment of joint pain secondary to aromatase inhibitor therapy in women with early breast cancer

Feasibility of use of acupuncture for treatment of arthralgia secondary to aromatase inhibitor therapy in women with early breast cancer


Sponsor

Royal Prince Alfred Hospital

Enrollment

30 participants

Start Date

Jul 20, 2009

Study Type

Interventional

Conditions

Summary

Breast cancer is most common cancer in women. Aproximately 75% of patients diagosed will have hormone receptor positive breast cancer. Tamoxifen has long been considered the gold standard for adjuvant therapy for postmenopausal women with endocrine sensitive early breast cancer. Aromatase inhibitors (AIs) are commonly used and are in fact superior in improving disease free survival. As a result, it is expected that in coming years the use of AIs in the current setting will increase dramatically. However, trials of AIs for breast cancer treatment have indicated that more than 40% of women taking AIs experience joint pain and stiffness which doesn't respond to conventional pain medication and may cause discontinuation of AI treatment. Acupuncture is one such alternative technique currentlyused for treating a variety of conditions including musculoskeletal pain. The analgesic mechanism of acupuncture is uncertain but it is speculated that analgesia may be mediated by release of opiod peptides and serotonin.


Eligibility

Sex: FemalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

Many women with breast cancer take a type of medication called aromatase inhibitors (AIs) to lower estrogen and reduce the risk of the cancer coming back. However, more than 40% of women on these drugs develop joint pain and stiffness as a side effect — pain that often does not respond to standard pain relievers. This study is testing whether acupuncture (a technique involving thin needles inserted at specific body points) can reduce this joint pain and help women stay on their important cancer medication. You may be eligible if: - You are a woman with early-stage breast cancer - You are currently taking a third-generation aromatase inhibitor (such as anastrozole, letrozole, or exemestane) - You have ongoing joint pain or stiffness in one or more joints that worsened after starting the aromatase inhibitor - Your pain score is at least 3 out of 10 on a pain scale You may NOT be eligible if: - You have previously used acupuncture for aromatase inhibitor-related joint pain - You have metastatic (advanced) breast cancer or a severe illness - You have a bleeding disorder, severe coagulopathy, or are taking warfarin or heparin - You have a cardiac pacemaker or other implanted electrical device - You have a needle phobia that prevents you from receiving acupuncture - You have significant intellectual or mental impairment Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Acupuncture twice weekly for 6 weeks. The sites which will be used are L14, LI11, GB34, ST40, Du20, Shishencong and Baxie on Day 1(First Session) and GB21, ST36, TH5, SP6 and LIV3 on Day 2 (Second Se

Acupuncture twice weekly for 6 weeks. The sites which will be used are L14, LI11, GB34, ST40, Du20, Shishencong and Baxie on Day 1(First Session) and GB21, ST36, TH5, SP6 and LIV3 on Day 2 (Second Session). In the treatment group the needles will be inserted with bilateral rotation until "de Qi" sensation is elicited. Electrical frequency will then be delivered over 2 to 10 Hz (as tolerated by the participant, 0.5 to 0.7 milliseconds duration pulse width for twenty minutes. Each session will take 30-60 minutes.


Locations(1)

Australia

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ACTRN12611000149965


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