CompletedPhase 3Phase 4ACTRN12611000772943
Comparison between intraarticular dexmedetomidine and morphine for postoperative analgesia after arthroscopic meniscal surgery
Sponsor
King Abdulaziz University
Enrollment
45 participants
Start Date
Apr 9, 2011
Study Type
Interventional
Conditions
Summary
This randomized double-blind study was designed to determine the analgesic effects of intra-articular dexmedetomidine and to compare it with those of morphine in patients undergoing arthroscopic knee surgery.
Eligibility
Sex: Both males and femalesMin Age: 18 Yearss
Inclusion Criteria3
- American Society of Anesthesiologists’ physical class I or II
- Arthroscopic meniscal surgery under general anaesthesia
- Elective surgery
Exclusion Criteria3
- Regional anaesthesia
- History of opioids or sedative agents use on regular basis for more than a week prior to surgery
- renal impairment (serum creatinine > 200 mcg/ml)
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Interventions
Arm 1: Intra-articular dexmedetomidine 1 mcg/kg (in 20 ml saline) before wound closure once
Arm 2: Intra-articular morphine 30 mcg/kg (in 20 ml saline) before wound closure once
Arm 1: Intra-articular dexmedetomidine 1 mcg/kg (in 20 ml saline) before wound closure once Arm 2: Intra-articular morphine 30 mcg/kg (in 20 ml saline) before wound closure once
Locations(1)
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ACTRN12611000772943
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