CompletedPhase 2ACTRN12611001150932
Dyslipidaemia, Oxidative Stress And Arterial Wall Function In Non-Insulin Dependent Diabetes
A Double-Blind Randomised Placebo-Controlled Trial Of The Effects Of Fenofibrate And Coenzyme Q10 On Arterial Function In Type 2 Diabetic Subjects With Dyslipidaemia
Sponsor
Professor Gerald F Watts
Enrollment
80 participants
Start Date
Feb 1, 1997
Study Type
Interventional
Conditions
Summary
To assess whether the combination of fenofibrate and coenzyme Q improves vascualr health in diabetes
Eligibility
Sex: Both males and femalesMin Age: 18 YearssMax Age: 75 Yearss
Inclusion Criteria2
- Type 2 diabetes
- Dyslipidaemia (fasting serum triglycaeride >1.8mmol/L or HDL-cholesterol <1.0mmol/L, with total cholesterol <6.5mmol/L and total cholesterol-to-HDL-cholesterol ratio >4)
Exclusion Criteria4
- Use of antioxidant or lipid-regulating therapy, insulin, angiotensin-converting enzyme inhibitors, calcium antagonists or aspirin
- Body mass index >40kg/m2
- Uncontrolled hypertension (>160/90mmHg)
- Serum creatinine >150umol/L
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Interventions
1.Fenofibrate 200mg/day orally
2.Coenzyme Q10 200mg/day orally
3.Fenofibrate 200mg/day plus Coezyme Q10 200mg/day orally
4.Placebo
All for 12 weeks
1.Fenofibrate 200mg/day orally 2.Coenzyme Q10 200mg/day orally 3.Fenofibrate 200mg/day plus Coezyme Q10 200mg/day orally 4.Placebo All for 12 weeks
Locations(1)
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ACTRN12611001150932
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