Investigation of whether metformin can be used safely and effectively in patients with type 2 diabetes on haemodialysis

This study is testing whether the diabetes medication metformin can be used safely in patients with type 2 diabetes who are on kidney dialysis. Metformin is usually not recommended for people with kidney failure because the drug can build up to dangerous levels. However, this study will give small doses of metformin after each dialysis session (when the drug is quickly cleared), to see whether this approach is safe and can still help control blood sugar. You may be eligible if: - You are 18 years of age or older - You have type 2 diabetes - You receive haemodialysis three times a week, and have done so for more than 3 months - Metformin would normally be prescribed for you if you had normal kidney function - You are able to self-monitor your blood glucose with a home glucometer You may NOT be eligible if: - You have moderate to severe heart failure, liver failure, or significant alcohol use - You have a major psychiatric disorder or are currently medically unstable - You are unable or unwilling to monitor your blood glucose levels at home - You cannot provide written informed consent Talk to your doctor about whether this trial might be right for you.