Is amitriptyline cream effective in the management of vestibulodynia - a condition which refers to pain at the opening of the vagina?

This study tests whether a cream containing amitriptyline (a medication usually used for nerve pain and depression) can relieve pain at the opening of the vagina, a condition called vestibulodynia. Women with this condition feel pain whenever pressure is applied to that area. The cream is applied directly to the skin and may reduce pain signals in the area. You may be eligible if: - You are a woman aged 18 or older - You have been diagnosed with provoked localized vestibulodynia (pain at the vaginal opening when touched) You may NOT be eligible if: - You have already had surgery to remove the painful tissue (vestibulectomy) - You have been treated with amitriptyline cream before - You are currently pregnant - You have an active vaginal or pelvic infection or yeast infection at the time of enrollment - You are unable to read or communicate in English Talk to your doctor about whether this trial might be right for you.