RecruitingACTRN12612001014842

Intraoperative fluid optimization of patients undergoing total hip or knee arthroplasty using pulse pressure variation obtained by a continuous noninvasive blood pressure monitor

The influence of fluid optimization using pulse pressure variation obtained by continuous noninvasive blood pressure monitor compared to standard perioperative pressure driven fluid management in the patients undergoing total hip or knee replacement under general anesthesia on the postoperative morbidity (number and rate of complications and length of stay)


Sponsor

Dpt. of Anesthesia and Intensive Care of The Faculty of Medicine Plzen - Charles University Prague)

Enrollment

80 participants

Start Date

Oct 1, 2012

Study Type

Interventional

Conditions

Summary

Aim of the trial is to evaluate the possibility of goal-directed fluid therapy during major orthopedic procedures under general anesthesia using protocol based on pulse pressure variation obtained by noninvasive continuous arterial pressure monitoring in comparison to standard usually given care. Influence on the postoperative outcome (number and rate of complications and hospital length of stay) will be assessed.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing a smarter way to manage intravenous fluids during hip or knee replacement surgery under general anaesthetic. Instead of giving a standard amount of fluid to all patients, researchers are using a special non-invasive blood pressure monitor to guide exactly how much fluid each patient needs in real time. The goal is to reduce complications after surgery and shorten hospital stays by keeping patients' circulation as stable as possible throughout the operation. You may be eligible if: - You are 18 years or older - You are scheduled for an elective hip or knee joint replacement surgery - You will have general anesthesia - You have a regular heart rhythm - You have given written informed consent You may NOT be eligible if: - You have an obvious blood flow problem in the arm being monitored - You have a vascular implant in the arm being monitored - You have a known neurological or neuromuscular condition affecting your upper limbs - You have peripheral (limb) oedema (swelling) Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Fluid optimization guided by the pulse pressure variation obtained by continuous noninvasive arterial pressure monitor (CNAP) based on the volume clamp method in addition to standard pressure/clinical

Fluid optimization guided by the pulse pressure variation obtained by continuous noninvasive arterial pressure monitor (CNAP) based on the volume clamp method in addition to standard pressure/clinical signs based fluid management during the surgical procedure.


Locations(1)

Czech Republic

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