A clinical study to assess the efficacy of a green-lipped mussel (GLM) extract in people with knee osteoarthritis.

Osteoarthritis of the knee causes pain, stiffness, and difficulty walking. This trial is testing a natural supplement made from green-lipped mussels (GlycOmega Plus) to see if it can reduce knee pain and improve movement and function. Previous studies without a placebo group showed promising results, and this study uses a proper placebo comparison to confirm whether the supplement truly works. Researchers will also look at gut bacteria to see if the supplement changes the bacterial balance in a way that reduces inflammation. You may be eligible if: - You are 40 to 85 years of age - You have had painful knee osteoarthritis for at least 6 months with a pain score of 4 or above - An x-ray has confirmed you have knee osteoarthritis (Kellgren-Lawrence grade 2 or 3) - You have not taken fish oils, glucosamine, green-lipped mussel, herbal supplements, antibiotics, or probiotics in the last 4 weeks You may NOT be eligible if: - You have had a knee replacement in the affected knee - You have had a cortisone injection or knee surgery in the past 3 months - You are pregnant - You have uncontrolled diabetes, high blood pressure, or cardiovascular disease - You have a shellfish allergy - You are unable to stop taking anti-inflammatory drugs (NSAIDs) for the duration of the trial Talk to your doctor about whether this trial might be right for you.