The Effect of Xylitol and Saline Nasal Irrigations on the Sinus Microbiome in Patients with Chronic Rhinosinusitis

This study is testing whether xylitol — a natural sugar substitute — can be used as a nasal rinse to reduce bacterial buildup in the sinuses of people with chronic rhinosinusitis (long-term sinus inflammation). Current antibiotics often struggle to clear the bacteria that form protective layers (biofilms) inside the sinuses. Xylitol may help break down these layers without antibiotics. You may be eligible if: - You are 16 years of age or older - You have been diagnosed with chronic rhinosinusitis - You are willing and able to give informed consent You may NOT be eligible if: - You have cystic fibrosis - You have a weakened immune system - You have a congenital problem with your cilia (the small hair-like structures in your airways) - You have fungal sinus disease - You have a systemic inflammatory or vascular condition - You have a history of cocaine abuse - You need sinus surgery for cancer - You are unable to consent due to mental incapacity Talk to your doctor about whether this trial might be right for you.